WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 504210
CAS#: 2076-91-7 (2HCl)
Description: TPT-260 2HCl, also known as R55, is a thiophene thiourea derivative with molecule weight 260.00 in free base form. There is no formal name yet, we temporally call this molecule as TPT-260. TPT260 acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~ 5 µM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP. **** Please also see similar products: TPT-197; TPT-260; TPT-172.
MedKoo Cat#: 504210
Name: TPT-260 2HCl (R55)
CAS#: 2076-91-7 (2HCl)
Chemical Formula: C8H12N4S3
Molecular Weight: 260.4
Elemental Analysis: Elemental Analysis: C, 28.83; H, 4.23; Cl, 21.27; N, 16.81; S, 28.86
TPT-260 2HCl (R55) , purity 98%, is in stock. The same day shipping out after order is received. Delivery time; overnight (USA/Canada) or 3-5 days (international). Same day shipping from Chapel Hill, USA. Shipping fee: from $30.00 (USA),from $45.00 (Canada); from $70.00 (international).
Related CAS #: 769856-81-7 (free base) 2076-91-7 (2HCl)
Synonym: TPT260; TPT-260; TPT 260; TPT-260 HCl; TPT-260 2HCl; TPT-260 dihydrchloride; R55. NSC-55712; NSC55712; NSC 55712
IUPAC/Chemical Name: thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride
InChi Key: DSODRWWHAUGSGD-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H12N4S3.2ClH/c9-7(10)13-3-5-1-2-6(15-5)4-14-8(11)12;;/h1-2H,3-4H2,(H3,9,10)(H3,11,12);2*1H
SMILES Code: NC(SCC1=CC=C(CSC(N)=N)S1)=N.[H]Cl.[H]Cl
The following data is based on the product molecular weight 260.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20. PubMed PMID: 24747528.