WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 504210
CAS#: 2076-91-7 (2HCl)
Description: TPT-260 2HCl, also known as R55, is a thiophene thiourea derivative with molecule weight 260.00 in free base form. There is no formal name yet, we temporally call this molecule as TPT-260. TPT260 acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~ 5 µM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP. **** Please also see similar products: TPT-197; TPT-260; TPT-172.
MedKoo Cat#: 504210
Name: TPT-260 2HCl (R55)
CAS#: 2076-91-7 (2HCl)
Chemical Formula: C8H12N4S3
Exact Mass:
Molecular Weight: 260.4
Elemental Analysis: Elemental Analysis: C, 28.83; H, 4.23; Cl, 21.27; N, 16.81; S, 28.86
Related CAS #: 769856-81-7 (free base) 2076-91-7 (2HCl)
Synonym: TPT260; TPT-260; TPT 260; TPT-260 HCl; TPT-260 2HCl; TPT-260 dihydrchloride; R55. NSC-55712; NSC55712; NSC 55712
IUPAC/Chemical Name: thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride
InChi Key: DSODRWWHAUGSGD-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H12N4S3.2ClH/c9-7(10)13-3-5-1-2-6(15-5)4-14-8(11)12;;/h1-2H,3-4H2,(H3,9,10)(H3,11,12);2*1H
SMILES Code: NC(SCC1=CC=C(CSC(N)=N)S1)=N.[H]Cl.[H]Cl
Appearance: White to off-white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO and in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 260.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20. PubMed PMID: 24747528.
