TPT-260 2HCl (R55)

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MedKoo CAT#: 504210

CAS#: 2076-91-7 (2HCl)

Description: TPT-260 2HCl, also known as R55, is a thiophene thiourea derivative with molecule weight 260.00 in free base form. There is no formal name yet, we temporally call this molecule as TPT-260. TPT260 acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~ 5 µM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP. **** Please also see similar products: TPT-197; TPT-260; TPT-172.

Chemical Structure

TPT-260 2HCl (R55)
CAS# 2076-91-7 (2HCl)

Theoretical Analysis

MedKoo Cat#: 504210
Name: TPT-260 2HCl (R55)
CAS#: 2076-91-7 (2HCl)
Chemical Formula: C8H12N4S3
Exact Mass:
Molecular Weight: 260.4
Elemental Analysis: Elemental Analysis: C, 28.83; H, 4.23; Cl, 21.27; N, 16.81; S, 28.86

Price and Availability

Size Price Availability Quantity
5.0mg USD 70.0 Same day
25.0mg USD 150.0 Same day
100.0mg USD 450.0 Same day
200.0mg USD 750.0 Same day
500.0mg USD 1550.0 Same day
1.0g USD 2650.0 Same day
2.0g USD 4750.0 Same day
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Related CAS #: 769856-81-7 (free base)   2076-91-7 (2HCl)    

Synonym: TPT260; TPT-260; TPT 260; TPT-260 HCl; TPT-260 2HCl; TPT-260 dihydrchloride; R55. NSC-55712; NSC55712; NSC 55712

IUPAC/Chemical Name: thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride


InChi Code: InChI=1S/C8H12N4S3.2ClH/c9-7(10)13-3-5-1-2-6(15-5)4-14-8(11)12;;/h1-2H,3-4H2,(H3,9,10)(H3,11,12);2*1H

SMILES Code: NC(SCC1=CC=C(CSC(N)=N)S1)=N.[H]Cl.[H]Cl

Appearance: White to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO and in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 260.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20. PubMed PMID: 24747528.