WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 504212
Description: TPT-197 is a thiophene thiourea derivative with molecule weight 197 in free base form. There is no formal name yet, we temporally call this molecule as TPT-197. Please also see similar products: TPT-197; TPT-260; TPT-172.
MedKoo Cat#: 504212
Name: TPT197 HCl
Chemical Formula: C7H7N3S2
Exact Mass: 197.00814
Molecular Weight: 197.28
Elemental Analysis: C, 35.97; H, 3.45; Cl, 15.17; N, 17.98; S, 27.44
Synonym: TPT197; TPT197; TPT 197.
IUPAC/Chemical Name: (5-cyanothiophen-2-yl)methyl carbamimidothioate hydrochloride.
InChi Key: SEXFLLDORYSNIB-UHFFFAOYSA-N
InChi Code: InChI=1S/C7H7N3S2.ClH/c8-3-5-1-2-6(12-5)4-11-7(9)10;/h1-2H,4H2,(H3,9,10);1H
SMILES Code: NC(SCC1=CC=C(C#N)S1)=N.[H]Cl
Appearance: white to off-white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in water
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 197.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20. PubMed PMID: 24747528.
Dr. Petskso's research recently published a new paper (Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508.). TPT-260 and TPT-172 were supplied by MedKoo Biosciences. Supplementary Text and Figures (1,865 KB) can be download for free.