M2912

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464962

CAS#: unknown

Description: M2912 is an Oral Tankyrase Inhibitor (IC50 = 0.6 nM) with Antitumor Activity in Colorectal Cancer Models.


Chemical Structure

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M2912
CAS# unknown

Theoretical Analysis

MedKoo Cat#: 464962
Name: M2912
CAS#: unknown
Chemical Formula: C17H18N2O2
Exact Mass: 282.1368
Molecular Weight: 282.343
Elemental Analysis: C, 72.32; H, 6.43; N, 9.92; O, 11.33

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: M2912; M 2912; M-2912;

IUPAC/Chemical Name: 3-(4-(2-hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one

InChi Key: MPXAEYSGFKRDQM-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H18N2O2/c1-11-4-9-15-16(20)18-14(10-19(11)15)12-5-7-13(8-6-12)17(2,3)21/h4-10,21H,1-3H3,(H,18,20)

SMILES Code: CC1=CC=C2N1C=C(C3=CC=C(C(O)(C)C)C=C3)NC2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 282.343 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Buchstaller HP, Anlauf U, Dorsch D, Kögler S, Kuhn D, Lehmann M, Leuthner B, Lodholz S, Musil D, Radtki D, Rettig C, Ritzert C, Rohdich F, Schneider R, Wegener A, Weigt S, Wilkinson K, Esdar C. Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J Med Chem. 2021 Jul 13. doi: 10.1021/acs.jmedchem.1c00800. Epub ahead of print. PMID: 34255518.

2: Torjesen I. NICE advises against using graded exercise therapy for patients recovering from covid-19. BMJ. 2020 Jul 21;370:m2912. doi: 10.1136/bmj.m2912. Erratum in: BMJ. 2020 Jul 22;370:m2933. PMID: 32694164.