WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464962
Description: M2912 is an Oral Tankyrase Inhibitor (IC50 = 0.6 nM) with Antitumor Activity in Colorectal Cancer Models.
MedKoo Cat#: 464962
Chemical Formula: C17H18N2O2
Exact Mass: 282.1368
Molecular Weight: 282.343
Elemental Analysis: C, 72.32; H, 6.43; N, 9.92; O, 11.33
This product is not in stock, which may be available by custom synthesis.
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Synonym: M2912; M 2912; M-2912;
IUPAC/Chemical Name: 3-(4-(2-hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one
InChi Key: MPXAEYSGFKRDQM-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H18N2O2/c1-11-4-9-15-16(20)18-14(10-19(11)15)12-5-7-13(8-6-12)17(2,3)21/h4-10,21H,1-3H3,(H,18,20)
SMILES Code: CC1=CC=C2N1C=C(C3=CC=C(C(O)(C)C)C=C3)NC2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 282.343 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Buchstaller HP, Anlauf U, Dorsch D, Kögler S, Kuhn D, Lehmann M, Leuthner B, Lodholz S, Musil D, Radtki D, Rettig C, Ritzert C, Rohdich F, Schneider R, Wegener A, Weigt S, Wilkinson K, Esdar C. Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J Med Chem. 2021 Jul 13. doi: 10.1021/acs.jmedchem.1c00800. Epub ahead of print. PMID: 34255518.
2: Torjesen I. NICE advises against using graded exercise therapy for patients recovering from covid-19. BMJ. 2020 Jul 21;370:m2912. doi: 10.1136/bmj.m2912. Erratum in: BMJ. 2020 Jul 22;370:m2933. PMID: 32694164.