WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 504211
CAS#: 32415-42-2 (HCl)
Description: TPT-172, also known as R33 (described in Mecozzi et al' s paper), is a thiophene thiourea derivative with molecule weight 172 in free base form. There is no formal name yet, we temporally call this molecule as TPT-172. Please also see similar products: TPT-197; TPT-260; TPT-172.
MedKoo Cat#: 504211
Name: TPT-172 HCl (R33)
CAS#: 32415-42-2 (HCl)
Chemical Formula: C6H9ClN2S2
Exact Mass: 207.9896
Molecular Weight: 208.7321
Elemental Analysis: C, 34.52; H, 4.35; Cl, 16.98; N, 13.42; S, 30.72
Related CAS #: 109841-87-4 (free base) 32415-42-2 (HCl)
Synonym: TPT172; TPT-172; TPT 172; thiophene thiourea derivative. R33
IUPAC/Chemical Name: thiophen-2-ylmethyl carbamimidothioate hydrochloride.
InChi Key: GFYZVDOORWWFNZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C6H8N2S2.ClH/c7-6(8)10-4-5-2-1-3-9-5;/h1-3H,4H2,(H3,7,8);1H
SMILES Code: NC(SCC1=CC=CS1)=N.[H]Cl
Appearance: white to off-white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO and water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in water
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 208.7321 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20. PubMed PMID: 24747528.
