TPT-172 HCl (R33)

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 504211

CAS#: 32415-42-2 (HCl)

Description: TPT-172, also known as R33 (described in Mecozzi et al' s paper), is a thiophene thiourea derivative with molecule weight 172 in free base form. There is no formal name yet, we temporally call this molecule as TPT-172. Please also see similar products: TPT-197; TPT-260; TPT-172.

Chemical Structure

TPT-172 HCl (R33)
CAS# 32415-42-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 504211
Name: TPT-172 HCl (R33)
CAS#: 32415-42-2 (HCl)
Chemical Formula: C6H9ClN2S2
Exact Mass: 207.9896
Molecular Weight: 208.7321
Elemental Analysis: C, 34.52; H, 4.35; Cl, 16.98; N, 13.42; S, 30.72

Price and Availability

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5.0mg USD 120.0 Same Day
10.0mg USD 150.0 Same Day
25.0mg USD 250.0 Same Day
50.0mg USD 450.0 Same Day
100.0mg USD 650.0 Same Day
200.0mg USD 950.0 Same Day
500.0mg USD 1950.0 Same Day
1.0g USD 3450.0 Same Day
2.0g USD 5250.0 Same Day
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Related CAS #: 109841-87-4 (free base)   32415-42-2 (HCl)    

Synonym: TPT172; TPT-172; TPT 172; thiophene thiourea derivative. R33

IUPAC/Chemical Name: thiophen-2-ylmethyl carbamimidothioate hydrochloride.


InChi Code: InChI=1S/C6H8N2S2.ClH/c7-6(8)10-4-5-2-1-3-9-5;/h1-3H,4H2,(H3,7,8);1H


Appearance: white to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO and water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in water

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 208.7321 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA. Pharmacological chaperones stabilize retromer to limit APP processing. Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20. PubMed PMID: 24747528.