WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406285
CAS#: 1314890-29-3
Description: TMP269 is a highly potent, selective and cell-permeable class IIa HDAC inhibitor with IC50 of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively.
MedKoo Cat#: 406285
Name: TMP269
CAS#: 1314890-29-3
Chemical Formula: C25H21F3N4O3S
Exact Mass: 514.12865
Molecular Weight: 514.52
Elemental Analysis: C, 58.36; H, 4.11; F, 11.08; N, 10.89; O, 9.33; S, 6.23
Synonym: TMP269; TMP 269; TMP-269
IUPAC/Chemical Name: N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
InChi Key: HORXBWNTEDOVKN-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H21F3N4O3S/c26-25(27,28)22-31-20(32-35-22)17-7-4-8-18(13-17)21(33)29-15-24(9-11-34-12-10-24)23-30-19(14-36-23)16-5-2-1-3-6-16/h1-8,13-14H,9-12,15H2,(H,29,33)
SMILES Code: O=C(NCC1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1)C4=CC=CC(C5=NOC(C(F)(F)F)=N5)=C4
1. Lobera M, et al. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. (2013) Nat Chem Biol. 9(5):319-25.
