WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464934

CAS#: 1132819-16-9

Description: Oxaliplatin-d10 is intended for use as an internal standard for the quantification of oxaliplatin by GC- or LC-MS. Oxaliplatin is a platinum-containing DNA-crosslinking agent. It induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein adducts, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells. Oxaliplatin is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.7 µM, respectively). It reduces tumor growth in an HCCLM3 mouse xenograft model when administered at doses of 5 or 10 mg/kg once per week. Formulations containing oxaliplatin have been used in the treatment of advanced colorectal cancer and as adjuvants in stage III colon cancer.

Chemical Structure

CAS# 1132819-16-9

Theoretical Analysis

MedKoo Cat#: 464934
Name: Oxaliplatin-d10
CAS#: 1132819-16-9
Chemical Formula: C8H4D10N2O4Pt
Exact Mass: 407.1229
Molecular Weight: 407.355
Elemental Analysis: C, 23.59; H, 5.93; N, 6.88; O, 15.71; Pt, 47.89

Price and Availability

Size Price Availability Quantity
1.0mg USD 930.0 2 Weeks
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Synonym: Oxaliplatin-d10; Oxaliplatin d10; Lipoxal-d10; Lipoxal d10;

IUPAC/Chemical Name: N/A


InChi Code: InChI=1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1/i1D2,2D2,3D2,4D2,5D,6D;;

SMILES Code: O=C1[O-][Pt+2]2([NH2][C@@]([2H])([C@@]3([NH2]2)[2H])C([2H])(C([2H])(C([2H])(C3([2H])[2H])[2H])[2H])[2H])[O-]C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 407.355 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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