WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 510213
CAS#: 84650-60-2 (Tea polyphenol)
Description: Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea. These chemical compounds are believed to be beneficial to human health, and they are the basis of many claims made about the health benefits of tea. Polyphenols are powerful antioxidants, which can reduce the risk of developing coronary artery disease and a number of other health problems. The compounds found in tea have also been linked with cancer reduction.
MedKoo Cat#: 510213
Name: Tea Polyphenol (TP98)
CAS#: 84650-60-2 (Tea polyphenol)
Related CAS #: 84650-60-2 (Tea polyphenol) 84650-60-2 (green tea extract)
Synonym: TP98, TP-98; TP 98; Tea Polyphenol; 98% Tea Polyphenol; Green tea extract.
IUPAC/Chemical Name: Tea polyphenol, flavanoids and tannins, green tea extract.
InChi Key: N/A
InChi Code: N/A
SMILES Code: N/A
Appearance: Light yellow to light pink solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Baladia E, Basulto J, Manera M, Martínez R, Calbet D. [Effect of green tea or green tea extract consumption on body weight and body composition; systematic review and meta-analysis]. Nutr Hosp. 2014 Mar 1;29(3):479-90. doi: 10.3305/nh.2014.29.3.7118. Review. Spanish. PubMed PMID: 24558988.
2: Wang X, Tian J, Jiang J, Li L, Ying X, Tian H, Nie M. Effects of green tea or green tea extract on insulin sensitivity and glycaemic control in populations at risk of type 2 diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials. J Hum Nutr Diet. 2014 Oct;27(5):501-12. doi: 10.1111/jhn.12181. Epub 2013 Nov 8. Review. PubMed PMID: 24206044.
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4: Khalesi S, Sun J, Buys N, Jamshidi A, Nikbakht-Nasrabadi E, Khosravi-Boroujeni H. Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials. Eur J Nutr. 2014 Sep;53(6):1299-311. doi: 10.1007/s00394-014-0720-1. Epub 2014 May 27. Review. PubMed PMID: 24861099.
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6: Fujiki H, Sueoka E, Watanabe T, Suganuma M. Primary cancer prevention by green tea, and tertiary cancer prevention by the combination of green tea catechins and anticancer compounds. J Cancer Prev. 2015 Mar;20(1):1-4. doi: 10.15430/JCP.2015.20.1.1. Review. PubMed PMID: 25853098; PubMed Central PMCID: PMC4384709.
7: Jówko E. Green Tea Catechins and Sport Performance. In: Lamprecht M, editor. Antioxidants in Sport Nutrition. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 8. PubMed PMID: 26065095.
8: Yiannakopoulou ECh. Effect of green tea catechins on breast carcinogenesis: a systematic review of in-vitro and in-vivo experimental studies. Eur J Cancer Prev. 2014 Mar;23(2):84-9. doi: 10.1097/CEJ.0b013e328364f23e. Review. PubMed PMID: 23939462.
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12: Fujiki H, Sueoka E, Watanabe T, Suganuma M. Synergistic enhancement of anticancer effects on numerous human cancer cell lines treated with the combination of EGCG, other green tea catechins, and anticancer compounds. J Cancer Res Clin Oncol. 2015 Sep;141(9):1511-22. doi: 10.1007/s00432-014-1899-5. Epub 2014 Dec 28. Review. PubMed PMID: 25544670.
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The composition of the tea leaves depends on a variety of factors, including climate, season, horticultural practices, and the type and age of the plant. The chemical composition of green tea is similar to that of the leaf. Green tea contains polyphenolic compounds, which include flavanols, flavandiols, flavonoids, and phenolic acids and account for 30% of the dry weight of green tea leaves. Most of the polyphenols in green tea are flavanols, commonly known as catechins; the major catechins in green tea are (2)-epicatechin, (2)-epicatechin-3-gallate, (2)-epigallocatechin, and (2)-epigallocatechin-3-gallate (EGCG). In black teas, the major polyphenols are theaflavin and thearubigin.
Major chemical compositions in tea polyphenol:
(-)-epicatechin (EC): (2R,3R)-2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol
(-)-epicatechin-3-gallate (ECG): (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate
(-)-epigallocatechin (EGC): (2R,3R)-2-(3,4,5-trihydroxyphenyl)chroman-3,5,7-triol
(-)-epigallocatechin-3-gallate (EGCG): (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate