Tea Polyphenol (TP98)
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MedKoo CAT#: 510213

CAS#: 84650-60-2 (Tea polyphenol)

Description: Tea polyphenol, also called green tea extract, are a mixture of chemical compounds, such as flavanoids and tannins, found naturally in tea. These chemical compounds are believed to be beneficial to human health, and they are the basis of many claims made about the health benefits of tea. Polyphenols are powerful antioxidants, which can reduce the risk of developing coronary artery disease and a number of other health problems. The compounds found in tea have also been linked with cancer reduction.


Chemical Structure

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Tea Polyphenol (TP98)
CAS# 84650-60-2 (Tea polyphenol)

Theoretical Analysis

MedKoo Cat#: 510213
Name: Tea Polyphenol (TP98)
CAS#: 84650-60-2 (Tea polyphenol)
Chemical Formula:
Exact Mass:
Molecular Weight:
Elemental Analysis:

Price and Availability

Size Price Availability Quantity
100.0g USD 350.0 Same day
500.0g USD 650.0 Same day
1.0kg USD 950.0 Same day
2.0kg USD 1650.0 2 Weeks
5.0kg USD 2650.0 2 Weeks
20.0kg USD 4950.0 2 Weeks
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Related CAS #: 84650-60-2 (Tea polyphenol)   84650-60-2 (green tea extract)    

Synonym: TP98, TP-98; TP 98; Tea Polyphenol; 98% Tea Polyphenol; Green tea extract.

IUPAC/Chemical Name: Tea polyphenol, flavanoids and tannins, green tea extract.

InChi Key: N/A

InChi Code: N/A

SMILES Code: N/A

Appearance: Light yellow to light pink solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Certificate of Analysis:

Safety Data Sheet (SDS):

Preparing Stock Solutions

The following data is based on the product molecular weight Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Baladia E, Basulto J, Manera M, Martínez R, Calbet D. [Effect of green tea or green tea extract consumption on body weight and body composition; systematic review and meta-analysis]. Nutr Hosp. 2014 Mar 1;29(3):479-90. doi: 10.3305/nh.2014.29.3.7118. Review. Spanish. PubMed PMID: 24558988.

2: Wang X, Tian J, Jiang J, Li L, Ying X, Tian H, Nie M. Effects of green tea or green tea extract on insulin sensitivity and glycaemic control in populations at risk of type 2 diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials. J Hum Nutr Diet. 2014 Oct;27(5):501-12. doi: 10.1111/jhn.12181. Epub 2013 Nov 8. Review. PubMed PMID: 24206044.

3: Li G, Zhang Y, Thabane L, Mbuagbaw L, Liu A, Levine MA, Holbrook A. Effect of green tea supplementation on blood pressure among overweight and obese adults: a systematic review and meta-analysis. J Hypertens. 2015 Feb;33(2):243-54. doi: 10.1097/HJH.0000000000000426. Review. PubMed PMID: 25479028.

4: Khalesi S, Sun J, Buys N, Jamshidi A, Nikbakht-Nasrabadi E, Khosravi-Boroujeni H. Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials. Eur J Nutr. 2014 Sep;53(6):1299-311. doi: 10.1007/s00394-014-0720-1. Epub 2014 May 27. Review. PubMed PMID: 24861099.

5: Hodgson AB, Randell RK, Jeukendrup AE. The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy and proposed mechanisms. Adv Nutr. 2013 Mar 1;4(2):129-40. doi: 10.3945/an.112.003269. Review. PubMed PMID: 23493529; PubMed Central PMCID: PMC3649093.

6: Fujiki H, Sueoka E, Watanabe T, Suganuma M. Primary cancer prevention by green tea, and tertiary cancer prevention by the combination of green tea catechins and anticancer compounds. J Cancer Prev. 2015 Mar;20(1):1-4. doi: 10.15430/JCP.2015.20.1.1. Review. PubMed PMID: 25853098; PubMed Central PMCID: PMC4384709.

7: Jówko E. Green Tea Catechins and Sport Performance. In: Lamprecht M, editor. Antioxidants in Sport Nutrition. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 8. PubMed PMID: 26065095.

8: Yiannakopoulou ECh. Effect of green tea catechins on breast carcinogenesis: a systematic review of in-vitro and in-vivo experimental studies. Eur J Cancer Prev. 2014 Mar;23(2):84-9. doi: 10.1097/CEJ.0b013e328364f23e. Review. PubMed PMID: 23939462.

9: Fritz H, Seely D, Kennedy DA, Fernandes R, Cooley K, Fergusson D. Green tea and lung cancer: a systematic review. Integr Cancer Ther. 2013 Jan;12(1):7-24. doi: 10.1177/1534735412442378. Epub 2012 Apr 24. Review. PubMed PMID: 22532034.

10: Teschke R, Zhang L, Melzer L, Schulze J, Eickhoff A. Green tea extract and the risk of drug-induced liver injury. Expert Opin Drug Metab Toxicol. 2014 Dec;10(12):1663-76. doi: 10.1517/17425255.2014.971011. Epub 2014 Oct 15. Review. PubMed PMID: 25316200.

11: Suganuma M, Takahashi A, Watanabe T, Iida K, Matsuzaki T, Yoshikawa HY, Fujiki H. Biophysical Approach to Mechanisms of Cancer Prevention and Treatment with Green Tea Catechins. Molecules. 2016 Nov 18;21(11). pii: E1566. Review. PubMed PMID: 27869750.

12: Fujiki H, Sueoka E, Watanabe T, Suganuma M. Synergistic enhancement of anticancer effects on numerous human cancer cell lines treated with the combination of EGCG, other green tea catechins, and anticancer compounds. J Cancer Res Clin Oncol. 2015 Sep;141(9):1511-22. doi: 10.1007/s00432-014-1899-5. Epub 2014 Dec 28. Review. PubMed PMID: 25544670.

13: Pazyar N, Feily A, Kazerouni A. Green tea in dermatology. Skinmed. 2012 Nov-Dec;10(6):352-5. Review. PubMed PMID: 23346663.

14: Albassam AA, Markowitz JS. An Appraisal of Drug-Drug Interactions with Green Tea (Camellia sinensis). Planta Med. 2017 Apr;83(6):496-508. doi: 10.1055/s-0043-100934. Epub 2017 Jan 24. Review. PubMed PMID: 28118673.

15: Ramshankar V, Krishnamurthy A. Chemoprevention of oral cancer: Green tea experience. J Nat Sci Biol Med. 2014 Jan;5(1):3-7. doi: 10.4103/0976-9668.127272. Review. PubMed PMID: 24678188; PubMed Central PMCID: PMC3961947.

16: Fujiki H, Imai K, Nakachi K, Shimizu M, Moriwaki H, Suganuma M. Challenging the effectiveness of green tea in primary and tertiary cancer prevention. J Cancer Res Clin Oncol. 2012 Aug;138(8):1259-70. doi: 10.1007/s00432-012-1250-y. Epub 2012 Jun 15. Review. PubMed PMID: 22699930.

17: Yang CS, Pan E. The effects of green tea polyphenols on drug metabolism. Expert Opin Drug Metab Toxicol. 2012 Jun;8(6):677-89. doi: 10.1517/17425255.2012.681375. Epub 2012 Apr 18. Review. PubMed PMID: 22509899.

18: Li G, Zhang Y, Mbuagbaw L, Holbrook A, Levine MA, Thabane L. Effect of green tea supplementation on blood pressure among overweight and obese adults: a protocol for a systematic review. BMJ Open. 2014 Apr 17;4(4):e004971. doi: 10.1136/bmjopen-2014-004971. Review. PubMed PMID: 24742977; PubMed Central PMCID: PMC3996813.

19: Suganuma M, Saha A, Fujiki H. New cancer treatment strategy using combination of green tea catechins and anticancer drugs. Cancer Sci. 2011 Feb;102(2):317-23. doi: 10.1111/j.1349-7006.2010.01805.x. Epub 2010 Dec 30. Review. PubMed PMID: 21199169.

20: Yuan JM. Green tea and prevention of esophageal and lung cancers. Mol Nutr Food Res. 2011 Jun;55(6):886-904. doi: 10.1002/mnfr.201000637. Epub 2011 Apr 29. Review. PubMed PMID: 21538848; PubMed Central PMCID: PMC3400335.



Additional Information

The composition of the tea leaves depends on a variety of factors, including climate, season, horticultural practices, and the type and age of the plant. The chemical composition of green tea is similar to that of the leaf. Green tea contains polyphenolic compounds, which include flavanols, flavandiols, flavonoids, and phenolic acids and account for 30% of the dry weight of green tea leaves. Most of the polyphenols in green tea are flavanols, commonly known as catechins; the major catechins in green tea are (2)-epicatechin, (2)-epicatechin-3-gallate, (2)-epigallocatechin, and (2)-epigallocatechin-3-gallate (EGCG). In black teas, the major polyphenols are theaflavin and thearubigin. 
  
Major chemical compositions in tea polyphenol:
(-)-epicatechin (EC):  (2R,3R)-2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol
(-)-epicatechin-3-gallate (ECG): (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate
(-)-epigallocatechin (EGC): (2R,3R)-2-(3,4,5-trihydroxyphenyl)chroman-3,5,7-triol
(-)-epigallocatechin-3-gallate (EGCG): (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate