Nolpitantium besilate

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MedKoo CAT#: 414455

CAS#: 155418-06-7 (besilate)

Description: Nolpitantium besilate is a neurokinin-1 receptor antagonist.


Chemical Structure

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Nolpitantium besilate
CAS# 155418-06-7 (besilate)

Theoretical Analysis

MedKoo Cat#: 414455
Name: Nolpitantium besilate
CAS#: 155418-06-7 (besilate)
Chemical Formula: C43H50Cl2N2O5S
Exact Mass: 0.00
Molecular Weight: 777.840
Elemental Analysis: C, 66.40; H, 6.48; Cl, 9.11; N, 3.60; O, 10.28; S, 4.12

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 155418-06-7 (besilate); 155418-05-6 (free base)  

Synonym: Nolpitantium besilate; SR140333B; SR-140333B; SR 140333B

IUPAC/Chemical Name: 1-(2-((S)-3-(3,4-Dichlorophenyl)-1-((m-isopropoxyphenyl)acetyl)-3-piperidyl)ethyl)-4-phenylquinuclidinium benzenesulfonate

InChi Key: PQRLQZNKDQQMBC-LSYPWIJNSA-M

InChi Code: InChI=1S/C37H45Cl2N2O2.C6H6O3S/c1-28(2)43-32-11-6-8-29(24-32)25-35(42)40-19-7-14-37(27-40,31-12-13-33(38)34(39)26-31)18-23-41-20-15-36(16-21-41,17-22-41)30-9-4-3-5-10-30;7-10(8,9)6-4-2-1-3-5-6/h3-6,8-13,24,26,28H,7,14-23,25,27H2,1-2H3;1-5H,(H,7,8,9)/q+1;/p-1/t36?,37-,41?;/m1./s1

SMILES Code: O=C(N1C[C@@](CC[N+]23CCC(CC3)(C4=CC=CC=C4)CC2)(C5=CC=C(Cl)C(Cl)=C5)CCC1)CC6=CC=CC(OC(C)C)=C6.O=S(C7=CC=CC=C7)([O-])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 777.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jul-Aug;25(6):483-506. PMID: 12949633.

2: Umer A, Ługowska-Umer H, Schönborn-Kellenberger O, Korolkiewicz PK, Sein- Anand Ł, Kuziemski K, Korolkiewicz RP. Tachykinin Antagonists Reverse Ischemia/Reperfusion Gastrointestinal Motility Impairment in Rats. J Surg Res. 2020 Nov;255:510-516. doi: 10.1016/j.jss.2020.05.092. Epub 2020 Jul 3. PMID: 32629333.

3: Moreaux B, Nemmar A, Vincke G, Halloy D, Beerens D, Advenier C, Gustin P. Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs. Eur J Pharmacol. 2000 Nov 24;408(3):305-12. doi: 10.1016/s0014-2999(00)00763-9. PMID: 11090648.

4: Umer A, Ługowska-Umer H, Schönborn-Kellenberger O, Korolkiewicz PK, Sein- Anand Ł, Kocic I, Korolkiewicz RP. Tachykinin antagonists ameliorate surgically induced impairment of gastrointestinal motility in rats. Fundam Clin Pharmacol. 2020 Oct 15. doi: 10.1111/fcp.12616. Epub ahead of print. PMID: 33058252.

5: Abey HT, Fairlie DP, Moffatt JD, Balzary RW, Cocks TM. Protease-activated receptor-2 peptides activate neurokinin-1 receptors in the mouse isolated trachea. J Pharmacol Exp Ther. 2006 May;317(2):598-605. doi: 10.1124/jpet.105.097121. Epub 2006 Jan 24. PMID: 16434565.

6: Seegers HC, Hood VC, Kidd BL, Cruwys SC, Walsh DA. Enhancement of angiogenesis by endogenous substance P release and neurokinin-1 receptors during neurogenic inflammation. J Pharmacol Exp Ther. 2003 Jul;306(1):8-12. doi: 10.1124/jpet.103.050013. Epub 2003 Mar 26. PMID: 12660314.

7: Boichot E, Germain N, Emonds-Alt X, Advenier C, Lagente V. Effects of SR 140333 and SR 48968 on antigen and substance P-induced activation of guinea-pig alveolar macrophages. Clin Exp Allergy. 1998 Oct;28(10):1299-305. doi: 10.1046/j.1365-2222.1998.00398.x. PMID: 9824398.

8: Daoui S, Cui YY, Lagente V, Emonds-Alt X, Advenier C. A tachykinin NK3 receptor antagonist, SR 142801 (osanetant), prevents substance P-induced bronchial hyperreactivity in guinea-pigs. Pulm Pharmacol Ther. 1997 Oct- Dec;10(5-6):261-70. doi: 10.1006/pupt.1998.0104. PMID: 9778489.