WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464881
CAS#: 37418-69-2
Description: LZZ-02 is a novel inhibitor of the transcriptional activity of β-catenin, degrading the expression of β-catenin by stabilizing axin 2 and diminishing downstream proteins levels, including c-Myc and cyclin D1, effectively shrinking tumor xenograft derived from colonic cell lines.
MedKoo Cat#: 464881
Name: LZZ-02
CAS#: 37418-69-2
Chemical Formula: C15H12N2O3
Exact Mass: 268.0848
Molecular Weight: 268.272
Elemental Analysis: C, 67.16; H, 4.51; N, 10.44; O, 17.89
This product is not in stock, which may be available by custom synthesis.
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Synonym: LZZ-02; LZZ02; LZZ 02;
IUPAC/Chemical Name: (E)-3-((4-nitrophenyl)amino)-1-phenylprop-2-en-1-one
InChi Key: YLVNYJXXPXCCHE-ZHACJKMWSA-N
InChi Code: InChI=1S/C15H12N2O3/c18-15(12-4-2-1-3-5-12)10-11-16-13-6-8-14(9-7-13)17(19)20/h1-11,16H/b11-10+
SMILES Code: O=C(C1=CC=CC=C1)/C=C/NC2=CC=C([N+]([O-])=O)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 268.272 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Li B, Liang J, Lu F, Zeng G, Zhang J, Ma Y, Liu P, Wang Q, Zhou Q, Chen L. Discovery of Novel Inhibitor for WNT/β-Catenin Pathway by Tankyrase 1/2 Structure-Based Virtual Screening. Molecules. 2020 Apr 6;25(7):1680. doi: 10.3390/molecules25071680. PMID: 32268564; PMCID: PMC7180783.
