WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464881

CAS#: 37418-69-2

Description: LZZ-02 is a novel inhibitor of the transcriptional activity of β-catenin, degrading the expression of β-catenin by stabilizing axin 2 and diminishing downstream proteins levels, including c-Myc and cyclin D1, effectively shrinking tumor xenograft derived from colonic cell lines.

Chemical Structure

CAS# 37418-69-2

Theoretical Analysis

MedKoo Cat#: 464881
Name: LZZ-02
CAS#: 37418-69-2
Chemical Formula: C15H12N2O3
Exact Mass: 268.0848
Molecular Weight: 268.272
Elemental Analysis: C, 67.16; H, 4.51; N, 10.44; O, 17.89

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: LZZ-02; LZZ02; LZZ 02;

IUPAC/Chemical Name: (E)-3-((4-nitrophenyl)amino)-1-phenylprop-2-en-1-one


InChi Code: InChI=1S/C15H12N2O3/c18-15(12-4-2-1-3-5-12)10-11-16-13-6-8-14(9-7-13)17(19)20/h1-11,16H/b11-10+

SMILES Code: O=C(C1=CC=CC=C1)/C=C/NC2=CC=C([N+]([O-])=O)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 268.272 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Li B, Liang J, Lu F, Zeng G, Zhang J, Ma Y, Liu P, Wang Q, Zhou Q, Chen L. Discovery of Novel Inhibitor for WNT/β-Catenin Pathway by Tankyrase 1/2 Structure-Based Virtual Screening. Molecules. 2020 Apr 6;25(7):1680. doi: 10.3390/molecules25071680. PMID: 32268564; PMCID: PMC7180783.