A2793 | CAS#88349-90-0 | TRESK inhibitor

A2793
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556009

CAS#: 88349-90-0

Description: A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK). A2793 inhibited TWIK-related acid-sensitive K+ channel (TASK)-1 (100 µM, 53.4% ± 13, 5%, n = 5).

Chemical Structure

A2793

CAS# 88349-90-0

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 556009
Name: A2793
CAS#: 88349-90-0
Chemical Formula: C13H12ClNO3
Exact Mass: 265.05
Molecular Weight: 265.693
Elemental Analysis: C, 58.77; H, 4.55; Cl, 13.34; N, 5.27; O, 18.06

Price and Availability

Size	Price	Availability
100mg	USD 1250	2 Weeks
200mg	USD 1950	2 Weeks
500mg	USD 2850	2 Weeks
1g	USD 4850	2 Weeks
2g	USD 6050	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: A2793; A-2793; A2793;

IUPAC/Chemical Name: Ethyl 2-[(5-chloroquinolin-8-yl)oxy]acetate

InChi Key: JEMXUSHXYOXNFL-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H12ClNO3/c1-2-17-12(16)8-18-11-6-5-10(14)9-4-3-7-15-13(9)11/h3-7H,2,8H2,1H3

SMILES Code: O=C(OCC)COC1=C2N=CC=CC2=C(Cl)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	A2793 is a dual TWIK-related acid-sensitive K+ channel (TASK)-1/TRESK inhibitor, with an IC50 of 6.8 μM for mTRESK.
In vitro activity:	TBD
In vivo activity:	TBD

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	76.5	287.93
	Ethanol	25.0	94.09

Preparing Stock Solutions

The following data is based on the product molecular weight 265.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	TBD
In vitro protocol:	TBD
In vivo protocol:	TBD

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Lengyel M, Erdélyi F, Pergel E, Bálint-Polonka Á, Dobolyi A, Bozsaki P, Dux M, Király K, Hegedűs T, Czirják G, Mátyus P, Enyedi P. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660. doi: 10.1124/mol.118.115626. Epub 2019 Apr 12. PMID: 30979812.

2: Bosman WM, Bronkhorst MW. Een vrouw met een pijnlijke enkel [A woman with a painful ankle]. Ned Tijdschr Geneeskd. 2012;156(4):A2793. Dutch. PMID: 22278033.

3: Oehlmann M, Score AJ, Blow JJ. The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation. J Cell Biol. 2004 Apr 26;165(2):181-90. doi: 10.1083/jcb.200311044. Epub 2004 Apr 19. PMID: 15096526; PMCID: PMC2172031.

4: Prokhorova TA, Blow JJ. Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity. J Biol Chem. 2000 Jan 28;275(4):2491-8. doi: 10.1074/jbc.275.4.2491. PMID: 10644704; PMCID: PMC3626232.

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