WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464850
Description: MS1768 is a DRD2 biased ligand.
MedKoo Cat#: 464850
Chemical Formula: C20H30ClN3O
Exact Mass: 363.2077
Molecular Weight: 363.93
Elemental Analysis: C, 66.01; H, 8.31; Cl, 9.74; N, 11.55; O, 4.40
This product is not in stock, which may be available by custom synthesis.
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Synonym: MS1768; MS 1768; MS-1768;
IUPAC/Chemical Name: 3-((1r,4r)-4-(2-(8-chloro-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1,1-dimethylurea
InChi Key: JKRQNNXDKNTEDN-JCNLHEQBSA-N
InChi Code: InChI=1S/C20H30ClN3O/c1-23(2)20(25)22-17-8-6-15(7-9-17)10-12-24-13-11-16-4-3-5-19(21)18(16)14-24/h3-5,15,17H,6-14H2,1-2H3,(H,22,25)/t15-,17-
SMILES Code: ClC1=CC=CC2=C1CN(CC[C@H]3CC[C@H](N([H])C(N(C)C)=O)CC3)CC2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 363.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Shen Y, McCorvy JD, Martini ML, Rodriguiz RM, Pogorelov VM, Ward KM, Wetsel WC, Liu J, Roth BL, Jin J. D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine. J Med Chem. 2019 May 9;62(9):4755-4771. doi: 10.1021/acs.jmedchem.9b00508. Epub 2019 Apr 18. PMID: 30964661; PMCID: PMC6509010.