MS1768

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MedKoo CAT#: 464850

CAS#: 2349365-88-2

Description: MS1768 is a potent D2 Dopamine Receptor G Protein-Biased Partial Agonist. MS1768 selectively activates the Gi/o pathway over β-arrestin2. Unlike the dual D2R/D3R partial agonist cariprazine, MS1768 showed selective agonist activity for D2R over D3R.MS1768 exhibited potent antagonism of dopamine-stimulated β-arrestin2 recruitment. MS1768 directly interacts with S1935.42 on TM5 but has no interactions with extracellular loop 2, which appears to be in contrast to the binding poses of D2R β-arrestin2-biased ligands. In in vivo studies, MS1768showed high D2R receptor occupancy in mice and effectively inhibited phencyclidine-induced hyperlocomotion.

Chemical Structure

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MS1768
CAS# 2349365-88-2
Instruction

Theoretical Analysis

MedKoo Cat#: 464850
Name: MS1768
CAS#: 2349365-88-2
Chemical Formula: C20H30ClN3O
Exact Mass: 363.21
Molecular Weight: 363.930
Elemental Analysis: C, 66.01; H, 8.31; Cl, 9.74; N, 11.55; O, 4.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MS1768; MS 1768; MS-1768;

IUPAC/Chemical Name: 3-((1r,4r)-4-(2-(8-chloro-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1,1-dimethylurea

InChi Key: JKRQNNXDKNTEDN-JCNLHEQBSA-N

InChi Code: InChI=1S/C20H30ClN3O/c1-23(2)20(25)22-17-8-6-15(7-9-17)10-12-24-13-11-16-4-3-5-19(21)18(16)14-24/h3-5,15,17H,6-14H2,1-2H3,(H,22,25)/t15-,17-

SMILES Code: ClC1=CC=CC2=C1CN(CC[C@H]3CC[C@H](N([H])C(N(C)C)=O)CC3)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Functionally selective G protein-coupled receptor ligands are valuable tools for deciphering the roles of downstream signaling pathways that potentially contribute to therapeutic effects versus side effects.

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 363.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Shen Y, McCorvy JD, Martini ML, Rodriguiz RM, Pogorelov VM, Ward KM, Wetsel WC, Liu J, Roth BL, Jin J. D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine. J Med Chem. 2019 May 9;62(9):4755-4771. doi: 10.1021/acs.jmedchem.9b00508. Epub 2019 Apr 18. PMID: 30964661; PMCID: PMC6509010.