Opipramol Free Base

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MedKoo CAT#: 414401

CAS#: 315-72-0 (free base)

Description: Opipramol Free Base is a tricyclic antidepressant with actions similar to AMITRIPTYLINE.

Chemical Structure

Opipramol Free Base
CAS# 315-72-0 (free base)

Theoretical Analysis

MedKoo Cat#: 414401
Name: Opipramol Free Base
CAS#: 315-72-0 (free base)
Chemical Formula: C23H29N3O
Exact Mass: 363.2311
Molecular Weight: 363.51
Elemental Analysis: C, 76.00; H, 8.04; N, 11.56; O, 4.40

Price and Availability

Size Price Availability Quantity
5.0mg USD 211.0 2 Weeks
10.0mg USD 346.0 2 Weeks
25.0mg USD 574.0 2 Weeks
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Related CAS #: 315-72-0 (free base)   909-39-7 (HCl)  

Synonym: Opipramol Free Base; BRN0627076; BRN-0627076; BRN 0627076

IUPAC/Chemical Name: 1-Piperazineethanol, 4-(3-(5H-dibenz(b,f)azepin-5-yl)propyl)-


InChi Code: InChI=1S/C23H29N3O/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26/h1-4,6-11,27H,5,12-19H2


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 363.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Gahr M, Hiemke C, Connemann BJ. Update Opipramol [Update Opipramol]. Fortschr Neurol Psychiatr. 2017 Mar;85(3):139-145. German. doi: 10.1055/s-0043-100762. Epub 2017 Mar 20. PMID: 28320023.

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6: Rozanski V, Laux G, Schwarz J. The Dopamine Receptor Antagonism of Opipramol: Relevance to Parkinsonism? Clin Neuropharmacol. 2019 May/Jun;42(3):77-79. doi: 10.1097/WNF.0000000000000332. PMID: 30829882.

7: Jasinski JP, Pek AE, Siddaraju BP, Yathirajan HS, Narayana B. Opipramol dipicrate. Acta Crystallogr Sect E Struct Rep Online. 2010 Jul 10;66(Pt 8):o1979-80. doi: 10.1107/S1600536810026565. PMID: 21588296; PMCID: PMC3007231.

8: Betz R, Gerber T, Hosten E, Siddaraju BP, Yathirajan HS. Opipramol dihydro- chloride. Acta Crystallogr Sect E Struct Rep Online. 2011 Nov;67(Pt 11):o2994-5. doi: 10.1107/S1600536811042280. Epub 2011 Oct 22. PMID: 22220014; PMCID: PMC3247396.

9: Gale CK, Millichamp J. Generalised anxiety disorder. BMJ Clin Evid. 2011 Oct 27;2011:1002. PMID: 22030083; PMCID: PMC3275153.

10: Müller WE, Siebert B. Opipramol im Vergleich zu anderen Therapeutika--Neue pharmakologische Daten [Opipramol in comparison to other drugs--new pharmacologic data]. Fortschr Neurol Psychiatr. 1998 Dec;66 Suppl 1:S9-12. German. doi: 10.1055/s-2007-1001157. PMID: 9922920.