WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 414401
CAS#: 315-72-0 (free base)
Description: Opipramol Free Base is a tricyclic antidepressant with actions similar to AMITRIPTYLINE.
MedKoo Cat#: 414401
Name: Opipramol Free Base
CAS#: 315-72-0 (free base)
Chemical Formula: C23H29N3O
Exact Mass: 363.2311
Molecular Weight: 363.51
Elemental Analysis: C, 76.00; H, 8.04; N, 11.56; O, 4.40
Related CAS #: 315-72-0 (free base) 909-39-7 (HCl)
Synonym: Opipramol Free Base; BRN0627076; BRN-0627076; BRN 0627076
IUPAC/Chemical Name: 1-Piperazineethanol, 4-(3-(5H-dibenz(b,f)azepin-5-yl)propyl)-
InChi Key: YNZFUWZUGRBMHL-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H29N3O/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26/h1-4,6-11,27H,5,12-19H2
SMILES Code: OCCN1CCN(CCCN2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 363.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Gahr M, Hiemke C, Connemann BJ. Update Opipramol [Update Opipramol]. Fortschr Neurol Psychiatr. 2017 Mar;85(3):139-145. German. doi: 10.1055/s-0043-100762. Epub 2017 Mar 20. PMID: 28320023.
2: Krysta K, Murawiec S, Warchala A, Zawada K, Cubała WJ, Wiglusz MS, Jakuszkowiak-Wojten K, Krzystanek M, Krupka-Matuszczyk I. Modern indications for the use of opipramol. Psychiatr Danub. 2015 Sep;27 Suppl 1:S435-7. PMID: 26417811.
3: Fun HK, Loh WS, Siddegowda MS, Yathirajan HS, Narayana B. Opipramol. Acta Crystallogr Sect E Struct Rep Online. 2011 Jul 1;67(Pt 7):o1598. doi: 10.1107/S1600536811021131. Epub 2011 Jun 11. PMID: 21837006; PMCID: PMC3151965.
4: Bandelow B, Reitt M, Röver C, Michaelis S, Görlich Y, Wedekind D. Efficacy of treatments for anxiety disorders: a meta-analysis. Int Clin Psychopharmacol. 2015 Jul;30(4):183-92. doi: 10.1097/YIC.0000000000000078. PMID: 25932596.
5: Carpéné C, Les F, Mercader J, Gomez-Zorita S, Grolleau JL, Boulet N, Fontaine J, Iglesias-Osma MC, Garcia-Barrado MJ. Opipramol Inhibits Lipolysis in Human Adipocytes without Altering Glucose Uptake and Differently from Antipsychotic and Antidepressant Drugs with Adverse Effects on Body Weight Control. Pharmaceuticals (Basel). 2020 Mar 5;13(3):41. doi: 10.3390/ph13030041. PMID: 32151075; PMCID: PMC7151722.
6: Rozanski V, Laux G, Schwarz J. The Dopamine Receptor Antagonism of Opipramol: Relevance to Parkinsonism? Clin Neuropharmacol. 2019 May/Jun;42(3):77-79. doi: 10.1097/WNF.0000000000000332. PMID: 30829882.
7: Jasinski JP, Pek AE, Siddaraju BP, Yathirajan HS, Narayana B. Opipramol dipicrate. Acta Crystallogr Sect E Struct Rep Online. 2010 Jul 10;66(Pt 8):o1979-80. doi: 10.1107/S1600536810026565. PMID: 21588296; PMCID: PMC3007231.
8: Betz R, Gerber T, Hosten E, Siddaraju BP, Yathirajan HS. Opipramol dihydro- chloride. Acta Crystallogr Sect E Struct Rep Online. 2011 Nov;67(Pt 11):o2994-5. doi: 10.1107/S1600536811042280. Epub 2011 Oct 22. PMID: 22220014; PMCID: PMC3247396.
9: Gale CK, Millichamp J. Generalised anxiety disorder. BMJ Clin Evid. 2011 Oct 27;2011:1002. PMID: 22030083; PMCID: PMC3275153.
10: Müller WE, Siebert B. Opipramol im Vergleich zu anderen Therapeutika--Neue pharmakologische Daten [Opipramol in comparison to other drugs--new pharmacologic data]. Fortschr Neurol Psychiatr. 1998 Dec;66 Suppl 1:S9-12. German. doi: 10.1055/s-2007-1001157. PMID: 9922920.