Zingibroside R1
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MedKoo CAT#: 464828

CAS#: 80930-74-1

Description: Zingibroside R1 is a triterpene saponin and an active metabolite of ginsenoside Ro that has been found in P. japonicus. It is cytotoxic to B16/F10 murine melanoma cells (IC50 = 24.52 µg/ml) and inhibits tube formation by human umbilical vein endothelial cells (HUVECs) when used at a concentration of 40 µg/ml. Zingibroside R1 (25 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.


Chemical Structure

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Zingibroside R1
CAS# 80930-74-1

Theoretical Analysis

MedKoo Cat#: 464828
Name: Zingibroside R1
CAS#: 80930-74-1
Chemical Formula: C42H66O14
Exact Mass: 794.4453
Molecular Weight: 794.976
Elemental Analysis: C, 63.46; H, 8.37; O, 28.18

Price and Availability

Size Price Availability Quantity
1.0mg USD 230.0 2 Weeks
5.0mg USD 510.0 2 Weeks
10.0mg USD 840.0 2 Weeks
25.0mg USD 1450.0 2 Weeks
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Synonym: Zingibroside R1; Zingibroside-R1; Ginsenoside Z-R1; Ginsenoside ZR1; Ginsenoside Z R1; Polysciasaponin P5; Polysciasaponin-P5;

IUPAC/Chemical Name: (2S,3S,4S,5R,6R)-6-(((3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-carboxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy)-3,4-dihydroxy-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid

InChi Key: WJQOMUVKRDJBGZ-COUNGWPASA-N

InChi Code: InChI=1S/C42H66O14/c1-37(2)14-16-42(36(51)52)17-15-40(6)20(21(42)18-37)8-9-24-39(5)12-11-25(38(3,4)23(39)10-13-41(24,40)7)54-35-32(29(47)28(46)31(55-35)33(49)50)56-34-30(48)27(45)26(44)22(19-43)53-34/h8,21-32,34-35,43-48H,9-19H2,1-7H3,(H,49,50)(H,51,52)/t21-,22+,23-,24+,25-,26+,27-,28-,29-,30+,31-,32+,34-,35+,39-,40+,41+,42-/m0/s1

SMILES Code: O[C@H]1[C@H](O)[C@@H](C(O)=O)O[C@@H](O[C@@H]2C(C)(C)[C@@](CC[C@]3(C)[C@]4([H])CC=C5[C@@]3(C)CC[C@]6(C(O)=O)[C@@]5([H])CC(C)(C)CC6)([H])[C@]4(C)CC2)[C@@H]1O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 794.976 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zhan X, Wang WY, Fu J, Deng R, Li F, Dai XJ, Wang Y, Wu H. [Pharmacokinetics of Achyranthes bidentata on adjuvant arthritis rats by microdialysis and UHPLC- MS/MS]. Zhongguo Zhong Yao Za Zhi. 2019 Jan;44(2):364-371. Chinese. doi: 10.19540/j.cnki.cjcmm.20181101.006. PMID: 30989959.

2: Zhou QL, Xu W, Yang XW. [Chemical constituents of Chinese red ginseng]. Zhongguo Zhong Yao Za Zhi. 2016 Jan;41(2):233-249. Chinese. doi: 10.4268/cjcmm20160214. PMID: 28861969.

3: Piao XM, Huo Y, Kang JP, Mathiyalagan R, Zhang H, Yang DU, Kim M, Yang DC, Kang SC, Wang YP. Diversity of Ginsenoside Profiles Produced by Various Processing Technologies. Molecules. 2020 Sep 24;25(19):4390. doi: 10.3390/molecules25194390. PMID: 32987784; PMCID: PMC7582514.

4: Zheng SW, Xiao SY, Wang J, Hou W, Wang YP. Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites. Molecules. 2019 Aug 17;24(16):2985. doi: 10.3390/molecules24162985. PMID: 31426477; PMCID: PMC6721120.

5: Li J, Qi H, Qi LW, Yi L, Li P. Simultaneous determination of main phytoecdysones and triterpenoids in radix achyranthis bidentatae by high- performance liquid chromatography with diode array-evaporative light scattering detectors and mass spectrometry. Anal Chim Acta. 2007 Jul 23;596(2):264-72. doi: 10.1016/j.aca.2007.05.016. Epub 2007 May 21. PMID: 17631105.

6: Yoshizaki K, Devkota HP, Fujino H, Yahara S. Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus). Chem Pharm Bull (Tokyo). 2013;61(3):344-50. doi: 10.1248/cpb.c12-00764. Epub 2012 Dec 28. PMID: 23291557.

7: Chen Y, Zhao Z, Chen H, Yi T, Qin M, Liang Z. Chemical differentiation and quality evaluation of commercial Asian and American ginsengs based on a UHPLC- QTOF/MS/MS metabolomics approach. Phytochem Anal. 2015 Mar-Apr;26(2):145-60. doi: 10.1002/pca.2546. Epub 2014 Dec 2. PMID: 25448530.

8: Hasegawa H, Matsumiya S, Uchiyama M, Kurokawa T, Inouye Y, Kasai R, Ishibashi S, Yamasaki K. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med. 1994 Jun;60(3):240-3. doi: 10.1055/s-2006-959467. PMID: 8073091.

9: Tang JR, Chen G, Lu YC, Tang QY, Song WL, Lin Y, Li Y, Peng SF, Yang SC, Zhang GH, Hao B. Identification of two UDP-glycosyltransferases involved in the main oleanane-type ginsenosides in Panax japonicus var. major. Planta. 2021 Apr 5;253(5):91. doi: 10.1007/s00425-021-03617-0. PMID: 33818668.