Mafenide Free Base
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MedKoo CAT#: 414319

CAS#: 138-39-6 (free base)

Description: Mafenide Free Base is a sulfonamide that inhibits the enzyme CARBONIC ANHYDRASE and is used as a topical anti-bacterial agent, especially in burn therapy.


Chemical Structure

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Mafenide Free Base
CAS# 138-39-6 (free base)

Theoretical Analysis

MedKoo Cat#: 414319
Name: Mafenide Free Base
CAS#: 138-39-6 (free base)
Chemical Formula: C7H10N2O2S
Exact Mass: 186.0463
Molecular Weight: 186.23
Elemental Analysis: C, 45.15; H, 5.41; N, 15.04; O, 17.18; S, 17.22

Price and Availability

Size Price Availability Quantity
100.0mg USD 219.0 2 Weeks
250.0mg USD 344.0 2 Weeks
500.0mg USD 528.0 2 Weeks
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Related CAS #: 138-39-6 (free base)   12001-72-8 (propionate)   138-37-4 (HCl)   138-39-6 (acetate)  

Synonym: Mafenide Free Base; NSC34632; NSC-34632; NSC 34632

IUPAC/Chemical Name: 4-(aminomethyl)benzenesulfonamide

InChi Key: TYMRLRRVMHJFTF-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)

SMILES Code: NCc1ccc(S(=O)(N)=O)cc1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 186.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Rizzo JA, Martini AK, Pruskowski KA, Rowan MP, Niece KL, Akers KS. Thermal stability of mafenide and amphotericin B topical solution. Burns. 2018 Mar;44(2):475-480. doi: 10.1016/j.burns.2017.08.019. Epub 2017 Sep 19. PMID: 28935221.

2: Afshari A, Nguyen L, Kahn SA, Montgomery AC, Shinha T, Stratton C, Summitt B. The Effective Duration of Antimicrobial Activity of Mafenide Acetate After Reconstitution. J Burn Care Res. 2018 Aug 17;39(5):736-738. doi: 10.1093/jbcr/irx029. PMID: 29931082.

3: Afshari A, Nguyen L, Kahn SA, Summitt B. 2.5% Mafenide Acetate: A Cost- Effective Alternative to the 5% Solution for Burn Wounds. J Burn Care Res. 2017 Jan/Feb;38(1):e42-e47. doi: 10.1097/BCR.0000000000000425. PMID: 27606553.

4: Bandmann HJ, Breit R. The mafenide story. Br J Dermatol. 1973 Aug;89(2):219-21. PMID: 4269480.

5: Kahn SA, Afshari A, Nguyen L, Shinha T, Huff T, Montgomery AC, Stratton C, Summitt B. Hydrofiber Dressing Saturated With Mafenide Acetate Extends the Duration of Antimicrobial Activity. J Burn Care Res. 2017 Jul/Aug;38(4):e704-e707. doi: 10.1097/BCR.0000000000000455. PMID: 27775984.

6: Mendelson JA. Topical mafenide hydrochloride aqueous spray in initial management of massive contaminated wounds with devitalized tissue. Prehosp Disaster Med. 2001 Jul-Sep;16(3):172-4. doi: 10.1017/s1049023x00025930. PMID: 11875802.

7: Punjataewakupt A, Napavichayanun S, Aramwit P. The downside of antimicrobial agents for wound healing. Eur J Clin Microbiol Infect Dis. 2019 Jan;38(1):39-54. doi: 10.1007/s10096-018-3393-5. Epub 2018 Oct 5. PMID: 30291466.

8: Mafenide acetate cream: a review. Drugs. 1971;1(6):434-60. doi: 10.2165/00003495-197101060-00002. PMID: 4948236.

9: Firoz EF, Firoz BF, Williams JF, Henning JS. Allergic contact dermatitis to mafenide acetate: a case series and review of the literature. J Drugs Dermatol. 2007 Aug;6(8):825-8. PMID: 17763614.

10: Han C, Yang Y, Yu A, Guo L, Guan Q, Shen H, Jiao Q. Investigation on the mechanism of mafenide in inhibiting pyroptosis and the release of inflammatory factors. Eur J Pharm Sci. 2020 Apr 30;147:105303. doi: 10.1016/j.ejps.2020.105303. Epub 2020 Mar 12. PMID: 32173407.