WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 205582
Description: Glasdegib, also known as PF-04449913, is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway with potential antineoplastic activity. Hedgehog inhibitor PF-04449913 appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Constitutive activation of Hh pathway signaling has been observed in various types of malignancies.
MedKoo Cat#: 205582
Name: Glasdegib (PF-04449913)
Chemical Formula: C21H22N6O
Exact Mass: 374.18551
Molecular Weight: 374.44
Elemental Analysis: C, 67.36; H, 5.92; N, 22.44; O, 4.27
Synonym: PF04449913; PF-04449913; PF 04449913; PF4449913; PF-4449913; PF 4449913; Glasdegib.
IUPAC/Chemical Name: 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea
InChi Key: SFNSLLSYNZWZQG-VQIMIIECSA-N
InChi Code: InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1
SMILES Code: O=C(NC1=CC=C(C#N)C=C1)N[C@H]2C[C@H](C3=NC4=CC=CC=C4N3)N(C)CC2
1.Methods of determining combinations comprising interleukin-2 (IL-2) and targeted chemotherapeutics for the treatment of cancer By Gong, Hua From PCT Int. Appl. (2013), WO 2013044169 A1 20130328.