Pamidronate Disodium
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MedKoo CAT#: 100700

CAS#: 57248-88-1 (Pamidronate Disodium heptahydrate);

Description: Pamidronate disodium is the disodium salt of the synthetic bisphosphonate pamidronate. Although its mechanism of action is not completely understood, pamidronate appears to adsorb to calcium phosphate crystals in bone, blocking their dissolution by inhibiting osteoclast-mediated bone resorption. This agent does not inhibit bone mineralization and formation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).


Chemical Structure

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Pamidronate Disodium
CAS# 57248-88-1 (Pamidronate Disodium heptahydrate);

Theoretical Analysis

MedKoo Cat#: 100700
Name: Pamidronate Disodium
CAS#: 57248-88-1 (Pamidronate Disodium heptahydrate);
Chemical Formula: C3H23NNa2O14P2
Exact Mass:
Molecular Weight: 405.13
Elemental Analysis: C, 8.89; H, 5.72; N, 3.46; Na, 11.35; O, 55.29; P, 15.29

Price and Availability

Size Price Availability Quantity
100.0mg USD 90.0 Same day
250.0mg USD 150.0 Same day
500.0mg USD 190.0 Same day
1.0g USD 250.0 Same day
2.0g USD 350.0 Same day
5.0g USD 450.0 Same day
10.0g USD 550.0 Same day
25.0g USD 850.0 Same day
50.0g USD 1250.0 Same day
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Related CAS #: 57248-88-1 (Pamidronate Disodium heptahydrate); 40391-99-9 (Pamidronic acid)  

Synonym: US brand name: Aredia. Foreign brand name: Aminomux. Abbreviation: APD. Code name: GCP23339A.

IUPAC/Chemical Name: sodium (3-amino-1-hydroxypropane-1,1-diyl)bis(hydrogenphosphonate) heptahydrate

InChi Key: WUKFVUXKIJZXHK-UHFFFAOYSA-L

InChi Code: InChI=1S/C3H11NO7P2.2Na.7H2O/c4-2-1-3(5,10-12(6)7)11-13(8)9;;;;;;;;;/h5,12-13H,1-2,4H2,(H,6,7)(H,8,9);;;7*1H2/q;2*+1;;;;;;;/p-2

SMILES Code: OC(OP([O-])=O)(OP([O-])=O)CCN.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Na+].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 405.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Additional Information

  
DRUG DESCRIPTION
Aredia, pamidronate disodium (APD), is a bone-resorption inhibitor available in 30-mg or 90-mg vials for intravenous administration. Each 30-mg and 90-mg vial contains, respectively, 30 mg and 90 mg of sterile, lyophilized pamidronate disodium and 470 mg and 375 mg of mannitol, USP. The pH of a 1% solution of pamidronate disodium in distilled water is approximately 8.3. Aredia, a member of the group of chemical compounds known as bisphosphonates, is an analog of pyrophosphate. Pamidronate disodium is designated chemically as phosphonic acid (3-amino-1-hydroxypropylidene) bis-, disodium salt, pentahydrate, (APD). Pamidronate disodium is a white-to-practically-white powder. It is soluble in water and in 2N sodium hydroxide, sparingly soluble in 0.1N hydrochloric acid and in 0.1N acetic acid, and practically insoluble in organic solvents. Its molecular formula is C3H9NO7P2Na2•5H2O and its molecular weight is 369.1. Inactive Ingredients. Mannitol, USP, and phosphoric acid (for adjustment to pH 6.5 prior to lyophilization).
 
CLINICAL PHARMACOLOGY
The principal pharmacologic action of Aredia is inhibition of bone resorption. Although the mechanism of antiresorptive action is not completely understood, several factors are thought to contribute to this action. Aredia adsorbs to calcium phosphate (hydroxyapatite) crystals in bone and may directly block dissolution of this mineral component of bone. In vitro studies also suggest that inhibition of osteoclast activity contributes to inhibition of bone resorption. In animal studies, at doses recommended for the treatment of hypercalcemia, Aredia inhibits bone resorption apparently without inhibiting bone formation and mineralization. Of relevance to the treatment of hypercalcemia of malignancy is the finding that Aredia inhibits the accelerated bone resorption that results from osteoclast hyperactivity induced by various tumors in animal studies.