WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 414280
CAS#: 174844-73-6
Description: L-159884 is a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging
MedKoo Cat#: 414280
Name: L-159884
CAS#: 174844-73-6
Chemical Formula: C31H30N4O4S
Exact Mass: 554.1988
Molecular Weight: 554.67
Elemental Analysis: C, 67.13; H, 5.45; N, 10.10; O, 11.54; S, 5.78
This product is not in stock, which may be available by custom synthesis.
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Synonym: L-159884; L159884; L 159884
IUPAC/Chemical Name: N-((4'-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-[1,1'-biphenyl]-2-yl)sulfonyl)-4-methoxybenzamide
InChi Key: IRQSDNILKLKJIU-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H30N4O4S/c1-5-28-33-29-20(2)18-21(3)32-30(29)35(28)19-22-10-12-23(13-11-22)26-8-6-7-9-27(26)40(37,38)34-31(36)24-14-16-25(39-4)17-15-24/h6-18H,5,19H2,1-4H3,(H,34,36)
SMILES Code: CCc(n1)n(Cc2ccc(c3c(S(=O)(NC(c4ccc(OC)cc4)=O)=O)cccc3)cc2)c5c1c(C)cc(C)n5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 554.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Szabo Z, Speth RC, Brown PR, Kerenyi L, Kao PF, Mathews WB, Ravert HT, Hilton J, Rauseo P, Dannals RF, Zheng W, Lee S, Sandberg K. Use of positron emission tomography to study AT1 receptor regulation in vivo. J Am Soc Nephrol. 2001 Jul;12(7):1350-1358. doi: 10.1681/ASN.V1271350. PMID: 11423564.
2: Hilton J, Yokoi F, Dannals RF, Ravert HT, Szabo Z, Wong DF. Column-switching HPLC for the analysis of plasma in PET imaging studies. Nucl Med Biol. 2000 Aug;27(6):627-30. doi: 10.1016/s0969-8051(00)00125-6. PMID: 11056380.
3: Szabo Z, Kao PF, Burns HD, Gibson RE, Hamill TG, Ravert HT, Kim SE, Mathews WB, Musachio JL, Scheffel U, Dannals RF. Investigation of angiotensin II/AT1 receptors with carbon-11-L-159,884: a selective AT1 antagonist. J Nucl Med. 1998 Jul;39(7):1209-13. PMID: 9669396.
4: Hamill TG, Burns HD, Dannals RF, Mathews WB, Musachio JL, Ravert HT, Naylor EM. Development of [11C]L-159,884: a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging. Appl Radiat Isot. 1996 Feb;47(2):211-8. doi: 10.1016/0969-8043(95)00273-1. PMID: 8852629.
5: Owonikoko TK, Fabucci ME, Brown PR, Nisar N, Hilton J, Mathews WB, Ravert HT, Rauseo P, Sandberg K, Dannals RF, Szabo Z. In vivo investigation of estrogen regulation of adrenal and renal angiotensin (AT1) receptor expression by PET. J Nucl Med. 2004 Jan;45(1):94-100. PMID: 14734680; PMCID: PMC1828744.
6: Kim SE, Scheffel U, Szabo Z, Burns HD, Gibson RE, Ravert HT, Mathews WB, Hamill TG, Dannals RF. In vivo labeling of angiotensin II receptors with a carbon-11-labeled selective nonpeptide antagonist. J Nucl Med. 1996 Feb;37(2):307-11. PMID: 8667067.
