WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414280

CAS#: 174844-73-6

Description: L-159884 is a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging

Chemical Structure

CAS# 174844-73-6

Theoretical Analysis

MedKoo Cat#: 414280
Name: L-159884
CAS#: 174844-73-6
Chemical Formula: C31H30N4O4S
Exact Mass: 554.20
Molecular Weight: 554.670
Elemental Analysis: C, 67.13; H, 5.45; N, 10.10; O, 11.54; S, 5.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: L-159884; L159884; L 159884

IUPAC/Chemical Name: N-((4'-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)-[1,1'-biphenyl]-2-yl)sulfonyl)-4-methoxybenzamide


InChi Code: InChI=1S/C31H30N4O4S/c1-5-28-33-29-20(2)18-21(3)32-30(29)35(28)19-22-10-12-23(13-11-22)26-8-6-7-9-27(26)40(37,38)34-31(36)24-14-16-25(39-4)17-15-24/h6-18H,5,19H2,1-4H3,(H,34,36)

SMILES Code: CCc(n1)n(Cc2ccc(c3c(S(=O)(NC(c4ccc(OC)cc4)=O)=O)cccc3)cc2)c5c1c(C)cc(C)n5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 554.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Szabo Z, Speth RC, Brown PR, Kerenyi L, Kao PF, Mathews WB, Ravert HT, Hilton J, Rauseo P, Dannals RF, Zheng W, Lee S, Sandberg K. Use of positron emission tomography to study AT1 receptor regulation in vivo. J Am Soc Nephrol. 2001 Jul;12(7):1350-1358. doi: 10.1681/ASN.V1271350. PMID: 11423564.

2: Hilton J, Yokoi F, Dannals RF, Ravert HT, Szabo Z, Wong DF. Column-switching HPLC for the analysis of plasma in PET imaging studies. Nucl Med Biol. 2000 Aug;27(6):627-30. doi: 10.1016/s0969-8051(00)00125-6. PMID: 11056380.

3: Szabo Z, Kao PF, Burns HD, Gibson RE, Hamill TG, Ravert HT, Kim SE, Mathews WB, Musachio JL, Scheffel U, Dannals RF. Investigation of angiotensin II/AT1 receptors with carbon-11-L-159,884: a selective AT1 antagonist. J Nucl Med. 1998 Jul;39(7):1209-13. PMID: 9669396.

4: Hamill TG, Burns HD, Dannals RF, Mathews WB, Musachio JL, Ravert HT, Naylor EM. Development of [11C]L-159,884: a radiolabelled, nonpeptide angiotensin II antagonist that is useful for angiotensin II, AT1 receptor imaging. Appl Radiat Isot. 1996 Feb;47(2):211-8. doi: 10.1016/0969-8043(95)00273-1. PMID: 8852629.

5: Owonikoko TK, Fabucci ME, Brown PR, Nisar N, Hilton J, Mathews WB, Ravert HT, Rauseo P, Sandberg K, Dannals RF, Szabo Z. In vivo investigation of estrogen regulation of adrenal and renal angiotensin (AT1) receptor expression by PET. J Nucl Med. 2004 Jan;45(1):94-100. PMID: 14734680; PMCID: PMC1828744.

6: Kim SE, Scheffel U, Szabo Z, Burns HD, Gibson RE, Ravert HT, Mathews WB, Hamill TG, Dannals RF. In vivo labeling of angiotensin II receptors with a carbon-11-labeled selective nonpeptide antagonist. J Nucl Med. 1996 Feb;37(2):307-11. PMID: 8667067.