WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464741
CAS#: unknown
Description: OICR766A is a novel Bax activator, having greatest effect enhancing the pro-apoptotic activity of Bax with EC50 values of ∼0.1 μM and ∼0.9 μM, respectively, inducing cell death by a Bax/Bak-dependent mechanism.
MedKoo Cat#: 464741
Name: OICR766A
CAS#: unknown
Chemical Formula: C25H26N4O
Exact Mass: 398.2107
Molecular Weight: 398.51
Elemental Analysis: C, 75.35; H, 6.58; N, 14.06; O, 4.01
This product is not in stock, which may be available by custom synthesis.
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Synonym: OICR766A; OICR 766A; OICR-766A;
IUPAC/Chemical Name: 3-((4-methylpiperazin-1-yl)(pyridin-2-yl)methyl)-2-phenyl-1H-indol-1-ol
InChi Key: KSPPFVMBFSONKS-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H26N4O/c1-27-15-17-28(18-16-27)25(21-12-7-8-14-26-21)23-20-11-5-6-13-22(20)29(30)24(23)19-9-3-2-4-10-19/h2-14,25,30H,15-18H2,1H3
SMILES Code: ON1C(C2=CC=CC=C2)=C(C(N3CCN(C)CC3)C4=NC=CC=C4)C5=C1C=CC=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 398.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Brahmbhatt H, Uehling D, Al-Awar R, Leber B, Andrews D. Small molecules reveal an alternative mechanism of Bax activation. Biochem J. 2016 Apr 15;473(8):1073-83. doi: 10.1042/BCJ20160118. Epub 2016 Feb 25. PMID: 26916338; PMCID: PMC4847155.
