Mabuterol hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576903

CAS#: 54240-36-7

Description: Mabuterol hydrochloride is a selective β2 adrenoreceptor agonist. Mabuterol has a specific effect on beta 2-adrenoceptors with no beta 1-stimulation.

Chemical Structure

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Mabuterol hydrochloride
CAS# 54240-36-7
Instruction

Theoretical Analysis

MedKoo Cat#: 576903
Name: Mabuterol hydrochloride
CAS#: 54240-36-7
Chemical Formula: C13H19Cl2F3N2O
Exact Mass: 346.08
Molecular Weight: 347.200
Elemental Analysis: C, 44.97; H, 5.52; Cl, 20.42; F, 16.42; N, 8.07; O, 4.61

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Broncholin; KF868; KF-868; KF 868; Mabuterol hydrochloride; Mabuterol HCl; PB 868; PB868; PB-868

IUPAC/Chemical Name: Benzenemethanol, 4-amino-3-chloro-alpha-(((1,1-dimethylethyl)amino)methyl)-5-(trifluoromethyl)-, monohydrochloride

InChi Key: MMCDXJOMPMIKGP-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H18ClF3N2O.ClH/c1-12(2,3)19-6-10(20)7-4-8(13(15,16)17)11(18)9(14)5-7;/h4-5,10,19-20H,6,18H2,1-3H3;1H

SMILES Code: [Cl-].CC(C)(C)[NH2+]CC(O)c1cc(Cl)c(N)c(c1)C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 347.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Song X, Zhao C, Dai C, Ren Y, An N, Wen H, Pan LI, Cheng M, Zhang Y. Suppression of the increasing level of acetylcholine-stimulated intracellular Ca(2+) in guinea pig airway smooth muscle cells by mabuterol. Biomed Rep. 2015 Nov;3(6):778-786. Epub 2015 Aug 4. PubMed PMID: 26623015; PubMed Central PMCID: PMC4660599.

2: Lu X, Liu P, Chen H, Qin F, Li F. Enantioselective pharmacokinetics of mabuterol in rats studied using sequential achiral and chiral HPLC. Biomed Chromatogr. 2005 Nov;19(9):703-8. PubMed PMID: 16206140.

3: Amemiya K, Asano T, Arika T, Nakamura M, Kudoh M. Special toxicology--physical dependence potential, antigenicity and mutagenicity--of mabuterol. Arzneimittelforschung. 1984;34(11A):1685-6. PubMed PMID: 6152162.

4: Tu Y, Zhong J, Wang H, Pan J, Xu Z, Yang W, Luo Y. Synthesis of stable isotope labeled D(9) -Mabuterol, D(9) -Bambuterol, and D(9) -Cimbuterol. J Labelled Comp Radiopharm. 2016 Nov;59(13):546-551. doi: 10.1002/jlcr.3446. Epub 2016 Oct 13. PubMed PMID: 27739098.

5: Osada E, Sakaya S, Sanai K, Seri K. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. III: Effects on the central nervous system, striated muscle and carbohydrate and lipid metabolism. Arzneimittelforschung. 1984;34(11A):1652-8. PubMed PMID: 6152158.

6: Yamamoto I, Matsuura E, Horiba M, Akima K, Nomura K, Aizawa T. Enzyme immunoassay for mabuterol, a selective beta 2-adrenergic stimulant in the trachea. J Immunoassay. 1985;6(3):261-76. PubMed PMID: 3900139.

7: Miyata T, Kai H, Furusawa K, Nakamura H, Saito M, Okano Y, Takahama K. Secretomotor and mucolytic effects of mabuterol, a novel bronchodilator. Arch Int Pharmacodyn Ther. 1987 Jul;288(1):147-60. PubMed PMID: 2889431.

8: Murai T, Maejima T, Sanai K, Osada E. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. I: Bronchodilating effect. Arzneimittelforschung. 1984;34(11A):1633-40. PubMed PMID: 6152156.

9: Guentert TW, Buskin JN, Galeazzi RL. Single dose pharmacokinetics of mabuterol in man. Arzneimittelforschung. 1984;34(11A):1691-6. PubMed PMID: 6152164.

10: Horiba M, Murai T, Nomura K, Yuge T, Sanai K, Osada E. Pharmacokinetic studies of mabuterol, a new selective beta 2-stimulant. II: Urinary metabolites of mabuterol in rats and their pharmacological effects. Arzneimittelforschung. 1984;34(11A):1668-79. PubMed PMID: 6152160.

11: Kawakami Y. First clinical studies on mabuterol. A summarizing report. Arzneimittelforschung. 1984;34(11A):1699-700. PubMed PMID: 6152166.

12: Amemiya K, Kudoh M, Suzuki H, Saga K, Hosaka K. Toxicology of mabuterol. Arzneimittelforschung. 1984;34(11A):1680-4. PubMed PMID: 6152161.

13: Ishizaki O, Daidohji S, Kimura K, Shibuya K, Horiguchi T, Sekiwa M. Reproduction studies with mabuterol in rats. Arzneimittelforschung. 1984;34(11A):1687-90. PubMed PMID: 6152163.

14: Osada E, Murai T, Ishizaka Y, Sanai K. Pharmacological studies of mabuterol, a new selective beta 2-stimulant. II: Effects on the cardiovascular system and smooth muscle organs. Arzneimittelforschung. 1984;34(11A):1641-51. PubMed PMID: 6152157.

15: Qureshi GA, Eriksson A. Determination of clenbuterol and mabuterol in equine plasma by ion-pair liquid chromatography with electrochemical detection. Chromatographic and electrochemical characteristics. J Chromatogr. 1988 May 27;441(1):197-205. PubMed PMID: 2900250.

16: Akahane K, Furukawa Y, Ogiwara Y, Haniuda M, Chiba S. Beta-adrenoceptor blocking effects of a selective beta 2-agonist, mabuterol, on the isolated, blood-perfused right atrium of the dog. Br J Pharmacol. 1989 Jul;97(3):709-16. PubMed PMID: 2474351; PubMed Central PMCID: PMC1854580.

17: Nakamura M, Yamaya M, Fukushima T, Sekizawa K, Sasaki H, Takishima T. Effect of mabuterol on tracheal mucociliary clearance of magnetized iron particles in anesthetized dogs. Respiration. 1991;58(1):33-6. PubMed PMID: 1677208.

18: Yuge T, Hase T, Takayanagi Y, Kamasuka T, Amemiya K, Horiba M. Pharmacokinetic studies of mabuterol, a new selective beta 2-stimulant. I: Studies on the absorption, distribution and excretion in rats. Arzneimittelforschung. 1984;34(11A):1659-67. PubMed PMID: 6152159.

19: Ulmer WT, Scholz HJ, Baines A. Pilot clinical trial with a new beta 2-sympathomimetic bronchodilator, mabuterol. Arzneimittelforschung. 1984;34(11A):1697-8. PubMed PMID: 6152165.