Maprotiline

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576875

CAS#: 10262-69-8

Description: Maprotiline is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.


Chemical Structure

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Maprotiline
CAS# 10262-69-8

Theoretical Analysis

MedKoo Cat#: 576875
Name: Maprotiline
CAS#: 10262-69-8
Chemical Formula: C20H23N
Exact Mass: 277.183
Molecular Weight: 277.41
Elemental Analysis: C, 86.59; H, 8.36; N, 5.05

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Maprotiline

IUPAC/Chemical Name: 9,10-Ethanoanthracene-9(10H)-propylamine, N-methyl-

InChi Key: QSLMDECMDJKHMQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3

SMILES Code: CNCCCC12CCC(c3ccccc13)c4ccccc24

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 277.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Schwartz L, Swaminathan S. Maprotiline hydrochloride and convulsions: a case report. Am J Psychiatry. 1982 Feb;139(2):244-5. PubMed PMID: 6798885.

2: Wells BG, Gelenberg AJ. Chemistry, pharmacology, pharmacokinetics, adverse effects, and efficacy of the antidepressant maprotiline hydrochloride. Pharmacotherapy. 1981 Sep-Oct;1(2):121-39. PubMed PMID: 6765485.

3: Atri PB, Julius DA. Maprotiline hydrochloride associated with a clinical state of catatonic stupor and epileptic encephalogram. J Clin Psychopharmacol. 1984 Aug;4(4):207-9. PubMed PMID: 6470193.

4: Multicenter evaluation of maprotiline hydrochloride for treatment of depression. Clin Ther. 1984;6(2):155-62. PubMed PMID: 6367987.

5: Treatment of depression with maprotiline hydrochloride: multicenter evaluation of efficacy and tolerability. Clin Ther. 1983;5(4):377-84. PubMed PMID: 6347381.