Exp6803

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 414177

CAS#: 114773-44-3

Description: Exp6803 is an Angiotensin II receptor antagonist.


Chemical Structure

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Exp6803
CAS# 114773-44-3

Theoretical Analysis

MedKoo Cat#: 414177
Name: Exp6803
CAS#: 114773-44-3
Chemical Formula: C25H26ClN3O5
Exact Mass: 483.16
Molecular Weight: 483.950
Elemental Analysis: C, 62.05; H, 5.42; Cl, 7.33; N, 8.68; O, 16.53

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Exp6803; Exp-6803; Exp 6803

IUPAC/Chemical Name: Methyl 2-n-butyl-1-(4-(2-carboxybenzamido)benzyl)-4-chloroimidazole-5-acetate

InChi Key: VPGBXMVPAQLPJI-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H26ClN3O5/c1-3-4-9-21-28-23(26)20(14-22(30)34-2)29(21)15-16-10-12-17(13-11-16)27-24(31)18-7-5-6-8-19(18)25(32)33/h5-8,10-13H,3-4,9,14-15H2,1-2H3,(H,27,31)(H,32,33)

SMILES Code: O=C(OC)CC1=C(Cl)N=C(CCCC)N1CC2=CC=C(NC(C3=CC=CC=C3C(O)=O)=O)C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 483.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wong PC, Price WA Jr, Chiu AT, Thoolen MJ, Duncia JV, Johnson AL, Timmermans PB. Nonpeptide angiotensin II receptor antagonists. IV. EXP6155 and EXP6803. Hypertension. 1989 May;13(5):489-97. doi: 10.1161/01.hyp.13.5.489. PMID: 2656519.

2: Wong PC, Price WA, Reilly TM, Duncia JV, Timmermans PB. Antihypertensive mechanism of captopril in renal hypertensive rats: studies with a nonpeptide angiotensin II receptor antagonist and an angiotensin II monoclonal antibody. J Pharmacol Exp Ther. 1989 Aug;250(2):515-22. PMID: 2668502.

3: Chiu AT, Duncia JV, McCall DE, Wong PC, Price WA Jr, Thoolen MJ, Carini DJ, Johnson AL, Timmermans PB. Nonpeptide angiotensin II receptor antagonists. III. Structure-function studies. J Pharmacol Exp Ther. 1989 Sep;250(3):867-74. PMID: 2778716.

4: Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Wexler RR, Johnson AL. Nonpeptide angiotensin II receptor antagonists. Am J Hypertens. 1990 Aug;3(8 Pt 1):599-604. doi: 10.1093/ajh/3.8.599. PMID: 2222950.

5: Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Wexler RR, Johnson AL. Angiotensin II receptor antagonists. From discovery to antihypertensive drugs. Hypertension. 1991 Nov;18(5 Suppl):III136-42. doi: 10.1161/01.hyp.18.5_suppl.iii136. PMID: 1937677.

6: Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Wexler RR, Johnson AL. Nonpeptide angiotensin II receptor antagonists: a novel class of antihypertensive agents. Blood Vessels. 1990;27(2-5):295-300. doi: 10.1159/000158821. PMID: 1978694.

7: Chiu AT, Dunscomb JH, McCall DE, Benfield P, Baubonis W, Sauer B. Characterization of angiotensin AT1A receptor isoform by its ligand binding signature. Regul Pept. 1993 Mar 19;44(2):141-7. doi: 10.1016/0167-0115(93)90237-3. PMID: 8469769.

8: Chiu AT, Dunscomb J, Kosierowski J, Burton CR, Santomenna LD, Corjay MH, Benfield P. The ligand binding signatures of the rat AT1A, AT1B and the human AT1 receptors are essentially identical. Biochem Biophys Res Commun. 1993 Dec 15;197(2):440-9. doi: 10.1006/bbrc.1993.2499. PMID: 8267579.

9: Sircar I, Winters RT, Quin J 3rd, Lu GH, Major TC, Panek RL. Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure- activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists. J Med Chem. 1993 Jun 11;36(12):1735-45. doi: 10.1021/jm00064a007. PMID: 8510101.