Manoalide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576869

CAS#: 75088-80-1

Description: Manoalide is a phospholipase A2 inhibitor and antiproliferative agent.


Chemical Structure

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Manoalide
CAS# 75088-80-1

Theoretical Analysis

MedKoo Cat#: 576869
Name: Manoalide
CAS#: 75088-80-1
Chemical Formula: C25H36O5
Exact Mass: 416.26
Molecular Weight: 416.560
Elemental Analysis: C, 72.08; H, 8.71; O, 19.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Manoalide

IUPAC/Chemical Name: 2(5H)-Furanone, 4-((2R,6R)-3,6-dihydro-6-hydroxy-5-((3E)-4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-hexenyl)-2H-pyran-2-yl)-5-hydroxy-, (5R)-

InChi Key: FGJIDQWRRLDGDB-CPIXEKRISA-N

InChi Code: InChI=1S/C25H36O5/c1-16(10-12-20-17(2)8-6-14-25(20,3)4)7-5-9-18-11-13-21(29-23(18)27)19-15-22(26)30-24(19)28/h7,11,15,21,23-24,27-28H,5-6,8-10,12-14H2,1-4H3/b16-7+/t21-,23-,24-/m1/s1

SMILES Code: C\C(=C/CCC1=CC[C@@H](O[C@H]1O)C2=CC(=O)O[C@H]2O)\CCC3=C(C)CCCC3(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 416.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Wang HR, Tang JY, Wang YY, Farooqi AA, Yen CY, Yuan SF, Huang HW, Chang HW. Manoalide Preferentially Provides Antiproliferation of Oral Cancer Cells by Oxidative Stress-Mediated Apoptosis and DNA Damage. Cancers (Basel). 2019 Sep 4;11(9):1303. doi: 10.3390/cancers11091303. PMID: 31487907; PMCID: PMC6770486.

2. Soriente A, De Rosa MM, Scettri A, Sodano G, Terencio MC, Payá M, Alcaraz MJ. Manoalide. Curr Med Chem. 1999 May;6(5):415-31. PMID: 10101221.

3. Wheeler LA, Sachs G, De Vries G, Goodrum D, Woldemussie E, Muallem S. Manoalide, a natural sesterterpenoid that inhibits calcium channels. J Biol Chem. 1987 May 15;262(14):6531-8. PMID: 2437121.

4. Glaser KB, de Carvalho MS, Jacobs RS, Kernan MR, Faulkner DJ. Manoalide: structure-activity studies and definition of the pharmacophore for phospholipase A2 inactivation. Mol Pharmacol. 1989 Nov;36(5):782-8. PMID: 2586492.