WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576864
Description: Manitimus is an inhibitor of dehydroorotate dehydrogenase and immunosuppresant.
MedKoo Cat#: 576864
Chemical Formula: C15H11F3N2O2
Exact Mass: 308.0773
Molecular Weight: 308.26
Elemental Analysis: C, 58.45; H, 3.60; F, 18.49; N, 9.09; O, 10.38
IUPAC/Chemical Name: 2-Hepten-6-ynamide, 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-, (Z)-
InChi Key: IRELROQHIPLASX-SEYXRHQNSA-N
InChi Code: InChI=1S/C15H11F3N2O2/c1-2-3-4-13(21)12(9-19)14(22)20-11-7-5-10(6-8-11)15(16,17)18/h1,5-8,21H,3-4H2,(H,20,22)/b13-12-
SMILES Code: O\C(=C(\C#N)/C(=O)Nc1ccc(cc1)C(F)(F)F)\CCC#C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 308.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Wlodarczyk Z, Vanrenterghem Y, Krämer BK, Squifflet JP, Ostrowski M. A multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation. BMC Nephrol. 2012 Jul 26;13:68. doi: 10.1186/1471-2369-13-68. PMID: 22835011; PMCID: PMC3418183.
2. Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Dec;27(10):711-38. PMID: 16395422.