Manitimus
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MedKoo CAT#: 576864

CAS#: 202057-76-9

Description: Manitimus is an inhibitor of dehydroorotate dehydrogenase and immunosuppresant.


Chemical Structure

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Manitimus
CAS# 202057-76-9

Theoretical Analysis

MedKoo Cat#: 576864
Name: Manitimus
CAS#: 202057-76-9
Chemical Formula: C15H11F3N2O2
Exact Mass: 308.0773
Molecular Weight: 308.26
Elemental Analysis: C, 58.45; H, 3.60; F, 18.49; N, 9.09; O, 10.38

Price and Availability

Size Price Availability Quantity
1.0mg USD 295.0 2 Weeks
5.0mg USD 635.0 2 Weeks
10.0mg USD 1045.0 2 Weeks
50.0mg USD 2425.0 2 Weeks
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Synonym: Manitimus

IUPAC/Chemical Name: 2-Hepten-6-ynamide, 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-, (Z)-

InChi Key: IRELROQHIPLASX-SEYXRHQNSA-N

InChi Code: InChI=1S/C15H11F3N2O2/c1-2-3-4-13(21)12(9-19)14(22)20-11-7-5-10(6-8-11)15(16,17)18/h1,5-8,21H,3-4H2,(H,20,22)/b13-12-

SMILES Code: O\C(=C(\C#N)/C(=O)Nc1ccc(cc1)C(F)(F)F)\CCC#C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 308.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Wlodarczyk Z, Vanrenterghem Y, Krämer BK, Squifflet JP, Ostrowski M. A multicenter, randomized, double-blind study comparing different FK778 doses (manitimus) with tacrolimus and steroids vs. MMF with tacrolimus and steroids in renal transplantation. BMC Nephrol. 2012 Jul 26;13:68. doi: 10.1186/1471-2369-13-68. PMID: 22835011; PMCID: PMC3418183.

2. Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2005 Dec;27(10):711-38. PMID: 16395422.