KU59403
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MedKoo CAT#: 406294

CAS#: 845932-30-1

Description: KU59403 is a potent and selective ATM (Ataxia telangiectasia mutated) inhibitor with with potential anticancer activity. KU59403 was not cytotoxic to human cancer cell lines (SW620, LoVo, HCT116, and MDA-MB-231) per se but significantly increased the cytotoxicity of topoisomerase I and II poisons: camptothecin, etoposide, and doxorubicin. KU59403 significantly enhanced the antitumor activity of topoisomerase poisons in mice bearing human colon cancer xenografts (SW620 and HCT116) at doses that were nontoxic alone and well-tolerated in combination


Price and Availability

Size Price Shipping out time Quantity
5mg USD 250 Same day
10mg USD 450 Same day
25mg USD 850 Same day
50mg USD 1450 Same day
100mg USD 2550 Same day
Inquire bulk and customized quantity

Pricing updated 2020-05-29. Prices are subject to change without notice.

KU59403, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406294
Name: KU59403
CAS#: 845932-30-1
Chemical Formula: C29H32N4O4S2
Exact Mass: 564.1865
Molecular Weight: 564.72
Elemental Analysis: C, 61.68; H, 5.71; N, 9.92; O, 11.33; S, 11.36


Synonym: KU59403; KU-59403; KU 59403

IUPAC/Chemical Name: 3-(4-methylpiperazin-1-yl)-N-(6-(6-morpholino-4-oxo-4H-pyran-2-yl)thianthren-2-yl)propanamide.

InChi Key: IIBZKDYAYJSSGB-UHFFFAOYSA-N

InChi Code: InChI=1S/C29H32N4O4S2/c1-31-9-11-32(12-10-31)8-7-27(35)30-20-5-6-24-26(17-20)38-25-4-2-3-22(29(25)39-24)23-18-21(34)19-28(37-23)33-13-15-36-16-14-33/h2-6,17-19H,7-16H2,1H3,(H,30,35)

SMILES Code: O=C(CCN1CCN(C)CC1)NC2=CC3=C(SC(C(C4=CC(C=C(N5CCOCC5)O4)=O)=CC=C6)=C6S3)C=C2.


Technical Data

Appearance:
Off-white to grey solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

  
 
 
 


References

1: Batey MA, Zhao Y, Kyle S, Richardson C, Slade A, Martin NM, Lau A, Newell DR,  Curtin NJ. Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer. Mol Cancer Ther. 2013 Jun;12(6):959-67. doi: 10.1158/1535-7163.MCT-12-0707. Epub 2013 Mar 19. PubMed PMID: 23512991; PubMed Central PMCID: PMC3736091.