WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 576863
Description: Manifaxine hydrochloride is a norepinephrine-dopamine reuptake inhibitor potentially for the treatment of attention deficit disorder.
MedKoo Cat#: 576863
Name: Manifaxine hydrochloride
Chemical Formula: C12H16ClF2NO2
Exact Mass: 279.0838
Molecular Weight: 279.71
Elemental Analysis: C, 51.53; H, 5.77; Cl, 12.67; F, 13.58; N, 5.01; O, 11.44
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: BW-1555U88; BW 1555U88; BW1555U88; Manifaxine hydrochloride; Manifaxine HCl
IUPAC/Chemical Name: 2-Morpholinol, 2-(3,5-difluorophenyl)-3,5-dimethyl-, hydrochloride, (2S-(2alpha,3alpha,5alpha))-
InChi Key: OZGPVYJHWWPEFT-RGNHYFCHSA-N
InChi Code: InChI=1S/C12H15F2NO2/c1-7-6-17-12(16,8(2)15-7)9-3-10(13)5-11(14)4-9/h3-5,7-8,15-16H,6H2,1-2H3/t7-,8+,12-/m1/s1
SMILES Code: C[C@@H]1CO[C@](O)([C@H](C)N1)c2cc(F)cc(F)c2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 279.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Spraggs CF, Pillai SG, Dow D, Douglas C, McCarthy L, Manasco PK, Stubbins M, Roses AD. Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects. Pharmacogenet Genomics. 2005 Dec;15(12):883-9. PubMed PMID: 16272960.
2: DeVeaugh-Geiss J, Conners CK, Sarkis EH, Winner PK, Ginsberg LD, Hemphill JM, Laurenza A, Barrows CE, Webster CJ, Stotka CJ, Asgharnejad M. GW320659 for the treatment of attention-deficit/hyperactivity disorder in children. J Am Acad Child Adolesc Psychiatry. 2002 Aug;41(8):914-20. PubMed PMID: 12162627.