Obovatal

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 111032

CAS#: 83864-77-1

Description: Obovatal is a biphenyl ether lignan from the leaves of Magnolia obovata Thunb

Chemical Structure

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Obovatal
CAS# 83864-77-1
Instruction

Theoretical Analysis

MedKoo Cat#: 111032
Name: Obovatal
CAS#: 83864-77-1
Chemical Formula: C18H16O4
Exact Mass: 296.10
Molecular Weight: 296.322
Elemental Analysis: C, 72.96; H, 5.44; O, 21.60

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: 3,4-Dihydroxy-5-(4-allylphenoxy)cinnamic aldehyde; Obovatal

IUPAC/Chemical Name: (E)-3-(3-(4-allylphenoxy)-4,5-dihydroxyphenyl)acrylaldehyde

InChi Key: KGHJODCHEIEYBP-HWKANZROSA-N

InChi Code: InChI=1S/C18H16O4/c1-2-4-13-6-8-15(9-7-13)22-17-12-14(5-3-10-19)11-16(20)18(17)21/h2-3,5-12,20-21H,1,4H2/b5-3+

SMILES Code: Oc1cc(\C=C\C=O)cc(Oc2ccc(CC=C)cc2)c1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 296.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Ito K, Iida T, Ichino K, Tsunezuka M, Hattori M, Namba T. Obovatol and obovatal, novel biphenyl ether lignans from the leaves of Magnolia obovata Thunb. Chem Pharm Bull (Tokyo). 1982 Sep;30(9):3347-53. doi: 10.1248/cpb.30.3347. PMID: 7172337.

2. Lee SK, Chun HK, Yang JY, Han DC, Son KH, Kwon BM. Inhibitory effect of obovatal on the migration and invasion of HT1080 cells via the inhibition of MMP-2. Bioorg Med Chem. 2007 Jun 15;15(12):4085-90. doi: 10.1016/j.bmc.2007.03.081. Epub 2007 Mar 30. PMID: 17428670.

3. Choi DY, Lee YJ, Lee SY, Lee YM, Lee HH, Choi IS, Oh KW, Han SB, Nam SY, Hong JT. Attenuation of scopolamine-induced cognitive dysfunction by obovatol. Arch Pharm Res. 2012 Jul;35(7):1279-86. doi: 10.1007/s12272-012-0719-1. Epub 2012 Aug 3. PMID: 22864751.

4. Joo J, Lee D, Wu Z, Shin JH, Lee HS, Kwon BM, Huh TL, Kim YW, Lee SJ, Kim TW, Lee T, Liu KH. In vitro metabolism of obovatol and its effect on cytochrome P450 enzyme activities in human liver microsomes. Biopharm Drug Dispos. 2013 May;34(4):195-202. doi: 10.1002/bdd.1837. Epub 2013 Mar 26. PMID: 23446989.

5. Seo KH, Lee DY, Lee DS, Park JH, Jeong RH, Jung YJ, Shrestha S, Chung IS, Kim GS, Kim YC, Baek NI. Neolignans from the fruits of Magnolia obovata and their inhibition effect on NO production in LPS-induced RAW 264.7 cells. Planta Med. 2013 Sep;79(14):1335-40. doi: 10.1055/s-0033-1350673. Epub 2013 Aug 22. PMID: 23970426.