Nacartocin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 111526

CAS#: 77727-10-7

Description: Nacartocin is an analog of oxytocin that is almost 3 times more potent as a natriuretic agent.

Chemical Structure

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Nacartocin
CAS# 77727-10-7
Instruction

Theoretical Analysis

MedKoo Cat#: 111526
Name: Nacartocin
CAS#: 77727-10-7
Chemical Formula: C46H71N11O11S
Exact Mass: 985.51
Molecular Weight: 986.200
Elemental Analysis: C, 56.02; H, 7.26; N, 15.62; O, 17.85; S, 3.25

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 50-56-6 (analog   oxytocin)  

Synonym:

IUPAC/Chemical Name: (S)-1-((4S,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-((S)-sec-butyl)-16-(4-ethylbenzyl)-6,9,12,15,18-pentaoxo-1-thia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)-N-((S)-1-((2-amino-2-oxoethyl)amino)-4-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide

InChi Key: JPYLEKXLHLKVBI-IHJZLXGESA-N

InChi Code: InChI=1S/C46H71N11O11S/c1-6-26(5)39-45(67)52-29(14-15-35(47)58)41(63)54-33(23-36(48)59)42(64)53-30(16-19-69-20-17-38(61)51-32(43(65)56-39)22-28-12-10-27(7-2)11-13-28)46(68)57-18-8-9-34(57)44(66)55-31(21-25(3)4)40(62)50-24-37(49)60/h10-13,25-26,29-34,39H,6-9,14-24H2,1-5H3,(H2,47,58)(H2,48,59)(H2,49,60)(H,50,62)(H,51,61)(H,52,67)(H,53,64)(H,54,63)(H,55,66)(H,56,65)/t26-,29-,30-,31-,32-,33-,34-,39-/m0/s1

SMILES Code: CC[C@@H]([C@@H]1NC([C@@H](NC(CCSCC[C@@H](C(N2CCC[C@H]2C(N[C@H](C(NCC(N)=O)=O)CC(C)C)=O)=O)NC([C@@H](NC([C@@H](NC1=O)CCC(N)=O)=O)CC(N)=O)=O)=O)Cc3ccc(CC)cc3)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 986.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Machová A, Schreiber V. The natriuretic effect of 1-24 ACTH in rats: a comparison with the natriuretic oxytocin analogue nacartocin. Physiol Bohemoslov. 1986;35(1):90-3. PMID: 3010351.

2: Gersl V, Hajzlerová K, Troppová V. The effects of nacartocin and oxytocin on the cardiovascular system of rabbits in vivo. Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove. 1985;28(3-5):165-80. PMID: 3870447.

3: Skopková J, Barth T, Hrbas P, Jost K, Lebel M. Natriuretic properties of [2-p-ethylphenylalanine] deamino-6-carba-oxytocin (Nacartocin) in cats. Exp Clin Endocrinol. 1984 Oct;84(2):235-8. doi: 10.1055/s-0029-1210393. PMID: 6543187.

4: Brest'ák M, Barth T, Rotta L, Servítová L, Jost K, Fuchs V. Nové úcinné inhibitory oxytocinu v testu na prouzku lidské dĕlohy in vitro [Effective new oxytocin inhibitors in tests on strips of the human uterus in vitro]. Cesk Gynekol. 1984 Jul;49(6):404-7. Czech. PMID: 6488334.

5: Hrbas P, Skopková J, Zicha J, Barth T, Lebl M, Jost K. Nacartocin--analogue of oxytocin with enhanced natriuretic properties: natriuretic and hemodynamic characteristics. Endocrinol Exp. 1984 Jun;18(2):117-24. PMID: 6611251.