Irinotecan HCl trihydrate

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 100480

CAS#: 136572-09-3 (HCl trihydrate)

Description: Irinotecan hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death.

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Irinotecan HCl trihydrate, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 30g may be 2 weeks.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 100480
Name: Irinotecan HCl trihydrate
CAS#: 136572-09-3 (HCl trihydrate)
Chemical Formula: C33H45ClN4O9 E
Exact Mass:
Molecular Weight: 677.18
Elemental Analysis: C, 58.53; H, 6.70; Cl, 5.23; N, 8.27; O, 21.26

Related CAS #: 136572-09-3 (HCl trihydrate)   100286-90-6 (HCl)   97682-44-5 (Free base)    

Synonym: CPT11; CPT-11; CPT 11; U101440E; HSDB 7607; HSDB-7607; HSDB7607; camptothecin-11; irinotecan; irinotecan HCl; Bbrand name: Camptosa; Campto.

IUPAC/Chemical Name: (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate.


InChi Code: InChI=1S/C33H38N4O6.ClH.3H2O/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2;;;;/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3;1H;3*1H2/t33-;;;;/m0..../s1

SMILES Code: O=C(N1CCC(N2CCCCC2)CC1)OC3=CC=C4N=C5C(CN6C(C(COC([C@@]7(CC)O)=O)=C7C=C65)=O)=C(CC)C4=C3.[H]Cl.[H]O[H].[H]O[H].[H]O[H]

Technical Data

Yellow solid powder

>98% (or refer to the Certificate of Analysis)

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:

Additional Information

Related CAS#
136572-09-3 (Irinotecan hydrocholide trihydrate);
100286-90-6 (Irinotecan hydrocholide);
97682-44-5 (Irinotecan Free base)


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