OBBA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 111015

CAS#: 133800-88-1

Description: OBBA is a phospholipase A2 antagonist.


Chemical Structure

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OBBA
CAS# 133800-88-1

Theoretical Analysis

MedKoo Cat#: 111015
Name: OBBA
CAS#: 133800-88-1
Chemical Formula: C28H44O3
Exact Mass: 428.329
Molecular Weight: 428.657
Elemental Analysis: C, 78.46; H, 10.35; O, 11.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 3-(4-octadecylbenzoyl)acrylic acid; 3-Obaa; 3 Obaa; 3Obaa; 4-Oxo-4-(3-(1-propylpentadecyl)phenyl)-2-butenoic acid; OBBA; 3-(4-Octadecyl)benzoylacrylic acid

IUPAC/Chemical Name: (E)-4-(3-(octadecan-4-yl)phenyl)-4-oxobut-2-enoic acid

InChi Key: OLTDVZPGSDCOGR-QURGRASLSA-N

InChi Code: InChI=1S/C28H44O3/c1-3-5-6-7-8-9-10-11-12-13-14-15-18-24(17-4-2)25-19-16-20-26(23-25)27(29)21-22-28(30)31/h16,19-24H,3-15,17-18H2,1-2H3,(H,30,31)/b22-21+

SMILES Code: CCCCCCCCCCCCCCC(CCC)c1cccc(c1)C(=O)\C=C\C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 428.657 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Kethineedi VR, Crivat G, Tarr MA, Rosenzweig Z. Quantum dot-NBD-liposome luminescent probes for monitoring phospholipase A2 activity. Anal Bioanal Chem. 2013 Dec;405(30):9729-37. doi: 10.1007/s00216-013-7422-z. Epub 2013 Oct 31. PMID: 24173659.

2. Sabirsh A, Bristulf J, Karlsson U, Owman C, Haeggström JZ. Non-specific effects of leukotriene synthesis inhibitors on HeLa cell physiology. Prostaglandins Leukot Essent Fatty Acids. 2005 Dec;73(6):431-40. doi: 10.1016/j.plefa.2005.08.004. Epub 2005 Sep 19. PMID: 16171988.

3. Nofer JR, Junker R, Walter M, Seedorf U, Assmann G, Zidek W, Tepel M. Phospholipase A(2) is involved in thapsigargin-induced sodium influx in human lymphocytes. Arch Biochem Biophys. 2000 Feb 15;374(2):213-21. doi: 10.1006/abbi.1999.1588. PMID: 10666300.

4. Abate A, Giessler J, Giessler C, Pönicke K, Hirschelmann R, Nuhn P. Inhibition of mediator release from anaphylactic guinea pig hearts by the novel phospholipase A2 inhibitor 3-(4-octadecylbenzoyl) acrylic acid. Inflamm Res. 1997 Aug;46 Suppl 2:S137-8. doi: 10.1007/s000110050143. PMID: 9297549.

5. Stanton PK. Phospholipase A2 activation is not required for long-term synaptic depression. Eur J Pharmacol. 1995 Feb 6;273(3):R7-9. doi: 10.1016/0014-2999(95)00022-d. PMID: 7737325.