Carboxymethyl cellulose
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 111522

CAS#: 9000-11-7 (free), 9004-32-4 (Na)

Description: Carboxymethyl cellulose is a cellulose derivative that is used as an emulsifier and thickener in cosmetics and eye drops.


Chemical Structure

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Carboxymethyl cellulose
CAS# 9000-11-7 (free), 9004-32-4 (Na)

Theoretical Analysis

MedKoo Cat#: 111522
Name: Carboxymethyl cellulose
CAS#: 9000-11-7 (free), 9004-32-4 (Na)
Chemical Formula: C8H16O8
Exact Mass: 240.08
Molecular Weight: 240.21
Elemental Analysis: C, 40.00; H, 6.71; O, 53.28

Price and Availability

Size Price Availability Quantity
500.0mg USD 580.0 2 Weeks
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Related CAS #: 9000-11-7 (free)    

Synonym: cellulose gum; CMC; C.M.C.; carboxymethylcellulose; carboxy methyl cellulose; carboxy-methyl-cellulose; carmellose; carbose; Apergel; Almelose; thylose; Tylose;

IUPAC/Chemical Name: acetic acid compound with 2,3,4,5,6-pentahydroxyhexanal (1:1)

InChi Key: VJHCJDRQFCCTHL-UHFFFAOYSA-N

InChi Code: InChI=1S/C6H12O6.C2H4O2/c7-1-3(9)5(11)6(12)4(10)2-8;1-2(3)4/h1,3-6,8-12H,2H2;1H3,(H,3,4)

SMILES Code: O=CC(O)C(O)C(O)C(O)CO.CC(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 240.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Manninen H, Sandell M, Mattila S, Hopia A, Laaksonen T. Comparing the taste- modifying properties of nanocellulose and carboxymethyl cellulose. J Food Sci. 2021 May;86(5):1928-1935. doi: 10.1111/1750-3841.15711. Epub 2021 May 4. PMID: 33942317.

2: Roy S, Kim HJ, Rhim JW. Effect of blended colorants of anthocyanin and shikonin on carboxymethyl cellulose/agar-based smart packaging film. Int J Biol Macromol. 2021 Apr 29;183:305-315. doi: 10.1016/j.ijbiomac.2021.04.162. Epub ahead of print. PMID: 33932410.

3: Rahman MS, Hasan MS, Nitai AS, Nam S, Karmakar AK, Ahsan MS, Shiddiky MJA, Ahmed MB. Recent Developments of Carboxymethyl Cellulose. Polymers (Basel). 2021 Apr 20;13(8):1345. doi: 10.3390/polym13081345. PMID: 33924089; PMCID: PMC8074295.

4: Sharratt WN, Lopez CG, Sarkis M, Tyagi G, O'Connell R, Rogers SE, Cabral JT. Ionotropic Gelation Fronts in Sodium Carboxymethyl Cellulose for Hydrogel Particle Formation. Gels. 2021 Apr 12;7(2):44. doi: 10.3390/gels7020044. PMID: 33921260.

5: Miehle E, Bader-Mittermaier S, Schweiggert-Weisz U, Hauner H, Eisner P. Effect of Physicochemical Properties of Carboxymethyl Cellulose on Diffusion of Glucose. Nutrients. 2021 Apr 21;13(5):1398. doi: 10.3390/nu13051398. PMID: 33919341.

6: Višić K, Pušić T, Čurlin M. Carboxymethyl Cellulose and Carboxymethyl Starch as Surface Modifiers and Greying Inhibitors in Washing of Cotton Fabrics. Polymers (Basel). 2021 Apr 6;13(7):1174. doi: 10.3390/polym13071174. PMID: 33917462; PMCID: PMC8038726.

7: Hu Y, Hu S, Zhang S, Dong S, Hu J, Kang L, Yang X. A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system. Sci Rep. 2021 Apr 28;11(1):9142. doi: 10.1038/s41598-021-88503-1. PMID: 33911150; PMCID: PMC8080826.

8: Mallakpour S, Tukhani M, Hussain CM. Recent advancements in 3D bioprinting technology of carboxymethyl cellulose-based hydrogels: Utilization in tissue engineering. Adv Colloid Interface Sci. 2021 Jun;292:102415. doi: 10.1016/j.cis.2021.102415. Epub 2021 Apr 20. PMID: 33892215.

9: Uyanga KA, Daoud WA. Carboxymethyl cellulose-chitosan composite hydrogel: Modelling and experimental study of the effect of composition on microstructure and swelling response. Int J Biol Macromol. 2021 Apr 20;181:1010-1022. doi: 10.1016/j.ijbiomac.2021.04.117. Epub ahead of print. PMID: 33892027.

10: Darvishi S, Javanbakht S, Heydari A, Kazeminava F, Gholizadeh P, Mahdipour M, Shaabani A. Ultrasound-assisted synthesis of MIL-88(Fe) coordinated to carboxymethyl cellulose fibers: A safe carrier for highly sustained release of tetracycline. Int J Biol Macromol. 2021 Apr 18;181:937-944. doi: 10.1016/j.ijbiomac.2021.04.092. Epub ahead of print. PMID: 33878359.

11: Haqiqi MT, Bankeeree W, Lotrakul P, Pattananuwat P, Punnapayak H, Ramadhan R, Kobayashi T, Amirta R, Prasongsuk S. Antioxidant and UV-Blocking Properties of a Carboxymethyl Cellulose-Lignin Composite Film Produced from Oil Palm Empty Fruit Bunch. ACS Omega. 2021 Mar 29;6(14):9653-9666. doi: 10.1021/acsomega.1c00249. PMID: 33869945; PMCID: PMC8047929.

12: Pagano C, Calarco P, Di Michele A, Ceccarini MR, Beccari T, Primavilla S, Scuota S, Marmottini F, Ramella D, Ricci M, Perioli L. Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation. Int J Pharm. 2021 Apr 20;602:120606. doi: 10.1016/j.ijpharm.2021.120606. Epub ahead of print. PMID: 33862131.

13: Rajendraprasad RM, Kwatra G, Batra N. Carboxymethyl Cellulose versus Hydroxypropyl Methylcellulose Tear Substitutes for Dry Eye Due to Computer Vision Syndrome: Comparison of Efficacy and Safety. Int J Appl Basic Med Res. 2021 Jan-Mar;11(1):4-8. doi: 10.4103/ijabmr.IJABMR_399_20. Epub 2021 Jan 26. PMID: 33842288; PMCID: PMC8025960.

14: Bagheri F, Darakhshan S, Mazloomi S, Shiri Varnamkhasti B, Tahvilian R. Dual loading of Nigella sativa oil-atorvastatin in chitosan-carboxymethyl cellulose nanogel as a transdermal delivery system. Drug Dev Ind Pharm. 2021 Apr;47(4):569-578. doi: 10.1080/03639045.2021.1892742. Epub 2021 Apr 5. PMID: 33819116.

15: Hai NTT, Cuong ND, Quyen NT, Hien NQ, Hien TTD, Phung NTT, Toan DK, Huong NTT, Phu DV, Hoa TT. Facile Synthesis of Carboxymethyl Cellulose Coated Core/Shell SiO2@Cu Nanoparticles and Their Antifungal Activity against Phytophthora capsici. Polymers (Basel). 2021 Mar 14;13(6):888. doi: 10.3390/polym13060888. PMID: 33799328; PMCID: PMC8001355.

16: An JM, Shahriar SMS, Hasan MN, Cho S, Lee YK. Carboxymethyl Cellulose, Pluronic, and Pullulan-Based Compositions Efficiently Enhance Antiadhesion and Tissue Regeneration Properties without Using Any Drug Molecules. ACS Appl Mater Interfaces. 2021 Apr 14;13(14):15992-16006. doi: 10.1021/acsami.0c21938. Epub 2021 Apr 2. PMID: 33797224.

17: Chen Q, Tai X, Li J, Li C, Guo L. High Internal Phase Emulsions Synergistically Stabilized by Sodium Carboxymethyl Cellulose and Palm Kernel Oil Ethoxylates as an Essential Oil Delivery System. J Agric Food Chem. 2021 Apr 14;69(14):4191-4203. doi: 10.1021/acs.jafc.0c07606. Epub 2021 Mar 31. PMID: 33787238.

18: Zhang D, Liu H, Chen M, Wang Q, Feng J, Shu X, Li C, Li Y, Xie X, Shi Q. A series of carboxymethyl cellulose-based antimicrobial peptide mimics were synthesized for antimicrobial applications. Carbohydr Polym. 2021 Jun 1;261:117822. doi: 10.1016/j.carbpol.2021.117822. Epub 2021 Feb 16. PMID: 33766332.

19: Maslamani N, Khan SB, Danish EY, Bakhsh EM, Zakeeruddin SM, Asiri AM. Super adsorption performance of carboxymethyl cellulose/copper oxide-nickel oxide nanocomposite toward the removal of organic and inorganic pollutants. Environ Sci Pollut Res Int. 2021 Mar 17. doi: 10.1007/s11356-021-13304-y. Epub ahead of print. PMID: 33733409.

20: Ali MSM, Zainal Z, Hussein MZ, Wahid MH, Bahrudin NN, Muzakir MM, Jalil R. Porous carboxymethyl cellulose carbon of lignocellulosic based materials incorporated manganese oxide for supercapacitor application. Int J Biol Macromol. 2021 Jun 1;180:654-666. doi: 10.1016/j.ijbiomac.2021.03.054. Epub 2021 Mar 13. PMID: 33722623.