OA 6129C

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 111001

CAS#: 82475-09-0

Description: OA 6129C is a new carbapenem antibiotic.


Chemical Structure

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OA 6129C
CAS# 82475-09-0

Theoretical Analysis

MedKoo Cat#: 111001
Name: OA 6129C
CAS#: 82475-09-0
Chemical Formula: C20H31N3O11S2
Exact Mass: 553.14
Molecular Weight: 553.598
Elemental Analysis: C, 43.39; H, 5.64; N, 7.59; O, 31.79; S, 11.58

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Synonym: OA 6129C; OA-6129C; OA6129C; Antibiotic OA 6129C; Antibiotic OA-6129C; Antibiotic OA6129C;

IUPAC/Chemical Name: 3-((2-(3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanamido)ethyl)thio)-7-oxo-6-(1-(sulfooxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

InChi Key: GRWWKENHBQJAML-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H31N3O11S2/c1-10(34-36(31,32)33)14-11-8-12(15(19(29)30)23(11)18(14)28)35-7-6-21-13(25)4-5-22-17(27)16(26)20(2,3)9-24/h10-11,14,16,24,26H,4-9H2,1-3H3,(H,21,25)(H,22,27)(H,29,30)(H,31,32,33)

SMILES Code: CC(C1C2CC(SCCNC(CCNC(C(C(C)(CO)C)O)=O)=O)=C(C(O)=O)N2C1=O)OS(=O)(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 553.598 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kojima I, Fukagawa Y, Okabe M, Ishikura T, Shibamoto N. Mutagenesis of OA-6129 carbapenem-producing blocked mutants and the biosynthesis of carbapenems. J Antibiot (Tokyo). 1988 Jul;41(7):899-907. doi: 10.7164/antibiotics.41.899. PMID: 3417564.

2: Kubo K, Ishikura T, Fukagawa Y. Microbial phosphorylation of the OA-6129 group of carbapenem compounds. J Antibiot (Tokyo). 1985 Mar;38(3):333-9. doi: 10.7164/antibiotics.38.333. PMID: 3839225.

3: Kubo K, Ishikura T, Fukagawa Y. Studies on the biosynthesis of carbapenem antibiotics. II. Isolation and functions of a specific acylase involved in the depantothenylation of the OA-6129 compounds. J Antibiot (Tokyo). 1984 Nov;37(11):1394-402. doi: 10.7164/antibiotics.37.1394. PMID: 6511667.

4: Fukagawa Y, Okabe M, Azuma S, Kojima I, Ishikura T, Kubo K. Studies on the biosynthesis of carbapenem antibiotics. I. Biosynthetic significance of the OA-6129 group of carbapenem compounds as the direct precursors for PS-5, epithienamycins A and C and MM 17880. J Antibiot (Tokyo). 1984 Nov;37(11):1388-93. doi: 10.7164/antibiotics.37.1388. PMID: 6511666.

5: Yoshioka T, Kojima I, Isshiki K, Watanabe A, Shimauchi Y, Okabe M, Fukagawa Y, Ishikura T. Structures of OA-6129A, B1, B2 and C, new carbapenem antibiotics produced by Streptomyces sp. OA-6129. J Antibiot (Tokyo). 1983 Nov;36(11):1473-82. doi: 10.7164/antibiotics.36.1473. PMID: 6654757.

6: Okabe M, Azuma S, Kojima I, Kouno K, Okamoto R, Fukagawa Y, Ishikura T. Studies on the OA-6129 group of antibiotics, new carbapenem compounds. I. Taxonomy, isolation and physical properties. J Antibiot (Tokyo). 1982 Oct;35(10):1255-63. doi: 10.7164/antibiotics.35.1255. PMID: 7174513.

OA 6129C

10.0mg / Not available