Macropa-NH2 diester

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555996

CAS#: 2146091-22-5

Description: Macropa-NH2 diester is used for making imaging agent cancer radio-diagnostic. Macropa-NH2 diester is compound 210 extracted from patent WO2018187631.

Chemical Structure

Macropa-NH2 diester
CAS# 2146091-22-5

Theoretical Analysis

MedKoo Cat#: 555996
Name: Macropa-NH2 diester
CAS#: 2146091-22-5
Chemical Formula: C29H43N5O8
Exact Mass: 589.31
Molecular Weight: 589.690
Elemental Analysis: C, 59.07; H, 7.35; N, 11.88; O, 21.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Synonym: Macropa-NH2 diester

IUPAC/Chemical Name: ethyl 4-amino-6-((16-((6-(methoxycarbonyl)pyridin-2-yl)methyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecan-7-yl)methyl)picolinate


InChi Code: InChI=1S/C29H43N5O8/c1-3-42-29(36)27-20-23(30)19-25(32-27)22-34-9-13-40-17-15-38-11-7-33(8-12-39-16-18-41-14-10-34)21-24-5-4-6-26(31-24)28(35)37-2/h4-6,19-20H,3,7-18,21-22H2,1-2H3,(H2,30,32)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 589.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kovács A. Theoretical Study of Actinide Complexes with Macropa. ACS Omega. 2020 Oct 6;5(41):26431-26440. doi: 10.1021/acsomega.0c02873. PMID: 33110971; PMCID: PMC7581080.

2: Thiele NA, Brown V, Kelly JM, Amor-Coarasa A, Jermilova U, MacMillan SN, Nikolopoulou A, Ponnala S, Ramogida CF, Robertson AKH, Rodríguez-Rodríguez C, Schaffer P, Williams C Jr, Babich JW, Radchenko V, Wilson JJ. An Eighteen- Membered Macrocyclic Ligand for Actinium-225 Targeted Alpha Therapy. Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14712-14717. doi: 10.1002/anie.201709532. Epub 2017 Oct 16. PMID: 28963750.

3: Thiele NA, MacMillan SN, Wilson JJ. Rapid Dissolution of BaSO4 by Macropa, an 18-Membered Macrocycle with High Affinity for Ba2. J Am Chem Soc. 2018 Dec 12;140(49):17071-17078. doi: 10.1021/jacs.8b08704. Epub 2018 Nov 28. PMID: 30485079; PMCID: PMC6560633.

4: Bell MM, Gutsche NT, King AP, Baidoo KE, Kelada OJ, Choyke PL, Escorcia FE. Glypican-3-Targeted Alpha Particle Therapy for Hepatocellular Carcinoma. Molecules. 2020 Dec 22;26(1):4. doi: 10.3390/molecules26010004. PMID: 33374953; PMCID: PMC7792624.

5: Thiele NA, Woods JJ, Wilson JJ. Implementing f-Block Metal Ions in Medicine: Tuning the Size Selectivity of Expanded Macrocycles. Inorg Chem. 2019 Aug 19;58(16):10483-10500. doi: 10.1021/acs.inorgchem.9b01277. Epub 2019 Jun 27. PMID: 31246017.

6: Li L, Rousseau J, Jaraquemada-Peláez MG, Wang X, Robertson A, Radchenko V, Schaffer P, Lin KS, Bénard F, Orvig C. 225Ac-H4py4pa for Targeted Alpha Therapy. Bioconjug Chem. 2020 Apr 9. doi: 10.1021/acs.bioconjchem.0c00171. Epub ahead of print. PMID: 32216377.

7: Thiele NA, Fiszbein DJ, Woods JJ, Wilson JJ. Tuning the Separation of Light Lanthanides Using a Reverse-Size Selective Aqueous Complexant. Inorg Chem. 2020 Nov 16;59(22):16522-16530. doi: 10.1021/acs.inorgchem.0c02413. Epub 2020 Oct 24. PMID: 33103417.

8: Aluicio-Sarduy E, Thiele NA, Martin KE, Vaughn BA, Devaraj J, Olson AP, Barnhart TE, Wilson JJ, Boros E, Engle JW. Establishing Radiolanthanum Chemistry for Targeted Nuclear Medicine Applications. Chemistry. 2020 Jan 27;26(6):1238-1242. doi: 10.1002/chem.201905202. Epub 2020 Jan 9. PMID: 31743504; PMCID: PMC7261199.

9: Reissig F, Bauer D, Ullrich M, Kreller M, Pietzsch J, Mamat C, Kopka K, Pietzsch HJ, Walther M. Recent Insights in Barium-131 as a Diagnostic Match for Radium-223: Cyclotron Production, Separation, Radiolabeling, and Imaging. Pharmaceuticals (Basel). 2020 Sep 25;13(10):272. doi: 10.3390/ph13100272. PMID: 32992909; PMCID: PMC7599757.

10: Yang H, Zhang C, Yuan Z, Rodriguez-Rodriguez C, Robertson A, Radchenko V, Perron R, Gendron D, Causey P, Gao F, Bénard F, Schaffer P. Synthesis and Evaluation of a Macrocyclic Actinium-225 Chelator, Quality Control and In Vivo Evaluation of 225 Ac-crown-αMSH Peptide. Chemistry. 2020 Sep 4;26(50):11435-11440. doi: 10.1002/chem.202002999. Epub 2020 Aug 28. PMID: 32588455.

11: Nelson BJB, Wilson J, Andersson JD, Wuest F. High yield cyclotron production of a novel 133/135La theranostic pair for nuclear medicine. Sci Rep. 2020 Dec 17;10(1):22203. doi: 10.1038/s41598-020-79198-x. PMID: 33335271; PMCID: PMC7747723.

12: Solomon VR, Barreto K, Bernhard W, Alizadeh E, Causey P, Perron R, Gendron D, Alam MK, Carr A, Geyer CR, Fonge H. Nimotuzumab Site-Specifically Labeled with 89Zr and 225Ac Using SpyTag/SpyCatcher for PET Imaging and Alpha Particle Radioimmunotherapy of Epidermal Growth Factor Receptor Positive Cancers. Cancers (Basel). 2020 Nov 20;12(11):3449. doi: 10.3390/cancers12113449. PMID: 33233524; PMCID: PMC7699480.

13: Kelly JM, Amor-Coarasa A, Ponnala S, Nikolopoulou A, Williams C Jr, Thiele NA, Schlyer D, Wilson JJ, DiMagno SG, Babich JW. A Single Dose of 225Ac-RPS-074 Induces a Complete Tumor Response in an LNCaP Xenograft Model. J Nucl Med. 2019 May;60(5):649-655. doi: 10.2967/jnumed.118.219592. Epub 2018 Nov 9. PMID: 30413660.

14: Zeidler W. New and additional records of hyperiidean amphipods of the infraorder Physosomata (Crustacea: Amphipoda: Hyperiidea) from the Antarctic Zone of the Southern Ocean. Zootaxa. 2019 Apr 3;4576(3):zootaxa.4576.3.5. doi: 10.11646/zootaxa.4576.3.5. PMID: 31715750.

15: Thiele NA, Wilson JJ. Actinium-225 for Targeted α Therapy: Coordination Chemistry and Current Chelation Approaches. Cancer Biother Radiopharm. 2018 Oct;33(8):336-348. doi: 10.1089/cbr.2018.2494. Epub 2018 Jun 11. PMID: 29889562; PMCID: PMC6207149.