WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 559351
Description: Macluraxanthone, a xanthone derivative, was previously reported to have many biological activities, including anti-cholinesterase, anti-oxidant, anti-cancer, anti-malarial and anti-inflammatory effects.
MedKoo Cat#: 559351
Chemical Formula: C23H22O6
Exact Mass: 394.1416
Molecular Weight: 394.42
Elemental Analysis: C, 70.04; H, 5.62; O, 24.34
This product is not in stock, which may be available by custom synthesis.
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Synonym: Macluraxanthone; NSC 107228; NSC107228; NSC-107228
IUPAC/Chemical Name: 2H,6H-Pyrano(3,2-b)xanthen-6-one, 12-(1,1-dimethyl-2-propenyl)-5,9,10-trihydroxy-2,2-dimethyl-
InChi Key: XRVLGJCHUWXTDX-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H22O6/c1-6-22(2,3)15-19-12(9-10-23(4,5)29-19)17(26)14-16(25)11-7-8-13(24)18(27)20(11)28-21(14)15/h6-10,24,26-27H,1H2,2-5H3
SMILES Code: CC(C)(C=C)c1c2Oc3c(O)c(O)ccc3C(=O)c2c(O)c4C=CC(C)(C)Oc14
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 394.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Ng IMJ, Mah SH, Chua CLL. Immuno-modulatory effects of macluraxanthone on macrophage phenotype and function. Nat Prod Res. 2020 Jun 8:1-6. doi: 10.1080/14786419.2020.1775223. Epub ahead of print. PMID: 32508145.
2. Xiang Q, Wu M, Zhang L, Fu W, Yang J, Zhang B, Zheng Z, Zhang H, Lao Y, Xu H. Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury. Front Pharmacol. 2020 Apr 15;11:452. doi: 10.3389/fphar.2020.00452. PMID: 32351391; PMCID: PMC7175665.