Maackiain

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 559329

CAS#: 2035-15-6

Description: Maackiain is a sophora flavescens derivative. Sophora flavescens has been applied to anti-allergic and anti-tumour treatments. Maackiain can increase IL-1β production by amplifying nigericin-mediated inflammasome activation


Chemical Structure

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Maackiain
CAS# 2035-15-6

Theoretical Analysis

MedKoo Cat#: 559329
Name: Maackiain
CAS#: 2035-15-6
Chemical Formula: C16H12O5
Exact Mass: 284.0685
Molecular Weight: 284.27
Elemental Analysis: C, 67.60; H, 4.26; O, 28.14

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Maackiain; Inermine; UNII-TF360D25IJ; UNII TF360D25IJ; UNIITF360D25IJ

IUPAC/Chemical Name: 6H-(1,3)Dioxolo(5,6)benzofuro(3,2-c)(1)benzopyran-3-ol, 6a,12a-dihydro-, (6aR-cis)-

InChi Key: HUKSJTUUSUGIDC-ZBEGNZNMSA-N

InChi Code: InChI=1S/C16H12O5/c17-8-1-2-9-12(3-8)18-6-11-10-4-14-15(20-7-19-14)5-13(10)21-16(9)11/h1-5,11,16-17H,6-7H2/t11-,16-/m0/s1

SMILES Code: Oc1ccc2[C@@H]3Oc4cc5OCOc5cc4[C@@H]3COc2c1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 284.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Huh JW, Lee JH, Jeon E, Ryu HW, Oh SR, Ahn KS, Jun HS, Ha UH. Maackiain, a compound derived from Sophora flavescens, increases IL-1β production by amplifying nigericin-mediated inflammasome activation. FEBS Open Bio. 2020 Aug;10(8):1482-1491. doi: 10.1002/2211-5463.12899. Epub 2020 Jun 26. PMID: 32428336; PMCID: PMC7396426.