WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 559329
Description: Maackiain is a sophora flavescens derivative. Sophora flavescens has been applied to anti-allergic and anti-tumour treatments. Maackiain can increase IL-1β production by amplifying nigericin-mediated inflammasome activation
MedKoo Cat#: 559329
Chemical Formula: C16H12O5
Exact Mass: 284.0685
Molecular Weight: 284.27
Elemental Analysis: C, 67.60; H, 4.26; O, 28.14
This product is not in stock, which may be available by custom synthesis.
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Synonym: Maackiain; Inermine; UNII-TF360D25IJ; UNII TF360D25IJ; UNIITF360D25IJ
IUPAC/Chemical Name: 6H-(1,3)Dioxolo(5,6)benzofuro(3,2-c)(1)benzopyran-3-ol, 6a,12a-dihydro-, (6aR-cis)-
InChi Key: HUKSJTUUSUGIDC-ZBEGNZNMSA-N
InChi Code: InChI=1S/C16H12O5/c17-8-1-2-9-12(3-8)18-6-11-10-4-14-15(20-7-19-14)5-13(10)21-16(9)11/h1-5,11,16-17H,6-7H2/t11-,16-/m0/s1
SMILES Code: Oc1ccc2[C@@H]3Oc4cc5OCOc5cc4[C@@H]3COc2c1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 284.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Huh JW, Lee JH, Jeon E, Ryu HW, Oh SR, Ahn KS, Jun HS, Ha UH. Maackiain, a compound derived from Sophora flavescens, increases IL-1β production by amplifying nigericin-mediated inflammasome activation. FEBS Open Bio. 2020 Aug;10(8):1482-1491. doi: 10.1002/2211-5463.12899. Epub 2020 Jun 26. PMID: 32428336; PMCID: PMC7396426.