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MedKoo CAT#: 559328

CAS#: 81-81-2

Description: Warfarin is used for its anticoagulant effect. Warfarin reaches a maximum plasma concentration between 2 and 6 hours after ingestion. It distributes into a small volume of distribution (10 L/70kg) and is eliminated by hepatic metabolism with a very small clearance (0.2 L/h/70kg). The elimination half-life is about 35 hours. Prothrombin complex synthesis is inhibited 50% at a warfarin concentration of about 1.5 mg/L. Warfarin is known to have interactions with azole antibiotics, macrolides, quinolones, nonsteroidal anti-inflammatory drugs, including selective cyclooxygenase-2 inhibitors, selective serotonin reuptake inhibitors, omeprazole, lipid-lowering agents, amiodarone, and fluorouracil.

Chemical Structure

CAS# 81-81-2

Theoretical Analysis

MedKoo Cat#: 559328
Name: Warfarin
CAS#: 81-81-2
Chemical Formula: C19H16O4
Exact Mass: 308.10
Molecular Weight: 308.330
Elemental Analysis: C, 74.01; H, 5.23; O, 20.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Synonym: Arab Rat Death; Athrombine-K; BRN 1293536; BRN1293536; BRN-1293536; Brumolin; Caswell No. 903; CO-Rax; Compound 42; Coumadin; Coumafen; Coumafene; Coumaphene; Coumarins; Cov-R-Tox; d-Con; Dethmor; Dethnel; Dicusat E; NSC 59813; Panwarfin; Prothromadin

IUPAC/Chemical Name: 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-


InChi Code: InChI=1S/C19H16O4/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22/h2-10,15,21H,11H2,1H3

SMILES Code: CC(=O)CC(C1=C(O)c2ccccc2OC1=O)c3ccccc3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 308.330000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Wells PS, Holbrook AM, Crowther NR, Hirsh J. Interactions of warfarin with drugs and food. Ann Intern Med. 1994 Nov 1;121(9):676-83. doi: 10.7326/0003-4819-121-9-199411010-00009. PMID: 7944078. Holford NH. Clinical pharmacokinetics and pharmacodynamics of warfarin. Understanding the dose-effect relationship. Clin Pharmacokinet. 1986 Nov-Dec;11(6):483-504. doi: 10.2165/00003088-198611060-00005. PMID: 3542339. Holbrook AM, Pereira JA, Labiris R, McDonald H, Douketis JD, Crowther M, Wells PS. Systematic overview of warfarin and its drug and food interactions. Arch Intern Med. 2005 May 23;165(10):1095-106. doi: 10.1001/archinte.165.10.1095. PMID: 15911722. Donaldson CJ, Harrington DJ. Therapeutic warfarin use and the extrahepatic functions of vitamin K-dependent proteins. Br J Biomed Sci. 2017 Oct;74(4):163-169. doi: 10.1080/09674845.2017.1336854. Epub 2017 Jun 28. PMID: 28657840.