CAY10784
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464671

CAS#: 1245814-52-1

Description: CAY10784 is a STAT3 inhibitor (IC50 = 0.74 µM in a reporter assay) and a derivative of WP1066. It inhibits proliferation of HeLa, Caco-2, A549, A375, U87MG, and HL-60 cancer cells (IC50s = 1.8, 1.8, 3, 2.8, 2.3, and 1.2 µM, respectively) but not PC3 or HT-29 cancer cells (IC50s = >10 µM for both). CAY10784 is also active against H. pylori and C. jejuni (MICs = 1.6 and 4.7 µM, respectively).


Chemical Structure

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CAY10784
CAS# 1245814-52-1

Theoretical Analysis

MedKoo Cat#: 464671
Name: CAY10784
CAS#: 1245814-52-1
Chemical Formula: C11H6F3N3O3S
Exact Mass: 317.01
Molecular Weight: 317.242
Elemental Analysis: C, 41.65; H, 1.91; F, 17.97; N, 13.25; O, 15.13; S, 10.11

Price and Availability

Size Price Availability Quantity
1mg USD 250 2 Weeks
5mg USD 650 2 Weeks
10mg USD 1050 2 Weeks
Bulk inquiry

Synonym: CAY10784; CAY 10784; CAY-10784;

IUPAC/Chemical Name: N-(5-nitrothiazol-2-yl)-4-(trifluoromethyl)benzamide

InChi Key: HKCGJKNZQDBZFT-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H6F3N3O3S/c12-11(13,14)7-3-1-6(2-4-7)9(18)16-10-15-5-8(21-10)17(19)20/h1-5H,(H,15,16,18)

SMILES Code: O=C(NC1=NC=C(S1)[N+]([O-])=O)C2=CC=C(C=C2)C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 30.0 94.58
DMF:PBS (pH 7.2) (1:2) 0.3 1.04
DMSO 10.0 31.53
Ethanol 1.0 3.15

Preparing Stock Solutions

The following data is based on the product molecular weight 317.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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