WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464663
Description: C0818 is a novel inducer of ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function.
MedKoo Cat#: 464663
Chemical Formula: C21H22ClNO5
Exact Mass: 403.1187
Molecular Weight: 403.859
Elemental Analysis: C, 62.46; H, 5.49; Cl, 8.78; N, 3.47; O, 19.81
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Synonym: C0818; C 0818; C-0818;
IUPAC/Chemical Name: 3,5-bis((E)-4-hydroxy-3-methoxybenzylidene)piperidin-4-one hydrochloride
InChi Key: NRULDJYGPFISDL-OBQHEISASA-N
InChi Code: InChI=1S/C21H21NO5.ClH/c1-26-19-9-13(3-5-17(19)23)7-15-11-22-12-16(21(15)25)8-14-4-6-18(24)20(10-14)27-2;/h3-10,22-24H,11-12H2,1-2H3;1H/b15-7+,16-8+;
SMILES Code: O=C1/C(CNC/C1=C\C2=CC=C(O)C(OC)=C2)=C/C3=CC=C(O)C(OC)=C3.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 403.859 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Abdelmoaty AAA, Zhang P, Lin W, Fan YJ, Ye SN, Xu JH. C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function. Acta Pharmacol Sin. 2021 Apr 6. doi: 10.1038/s41401-021-00642-3. Epub ahead of print. PMID: 33824458.
2: Fan Y, Liu Y, Zhang L, Cai F, Zhu L, Xu J. C0818, a novel curcumin derivative, interacts with Hsp90 and inhibits Hsp90 ATPase activity. Acta Pharm Sin B. 2017 Jan;7(1):91-96. doi: 10.1016/j.apsb.2016.05.014. Epub 2016 Jun 18. PMID: 28119813; PMCID: PMC5237709.