UJN-00411

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464626

CAS#: unknown

Description: UJN-00411 is a novel selective inhibitor of the transient receptor potential melastatin 2 (TRPM2) channel, exhibiting TRPM2 selectivity over TRPM8 and TRPV1 channels as well as phospholipase A2 and showing neuroprotective activity in vitro, and significantly reducing cerebral infarction in vivo. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

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UJN-00411
CAS# unknown
Instruction

Theoretical Analysis

MedKoo Cat#: 464626
Name: UJN-00411
CAS#: unknown
Chemical Formula: C23H16F3NO3
Exact Mass: 411.11
Molecular Weight: 411.380
Elemental Analysis: C, 67.15; H, 3.92; F, 13.85; N, 3.40; O, 11.67

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: UJN-00411; UJN 00411; UJN00411; TRPM2 inhibitor A23;

IUPAC/Chemical Name: (E)-2-(3-(3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)acrylamido)benzoic acid

InChi Key: UUTXSEXSQMSUEG-JLHYYAGUSA-N

InChi Code: InChI=1S/C23H16F3NO3/c24-23(25,26)18-5-3-4-17(14-18)16-11-8-15(9-12-16)10-13-21(28)27-20-7-2-1-6-19(20)22(29)30/h1-14H,(H,27,28)(H,29,30)/b13-10+

SMILES Code: O=C(O)C1=CC=CC=C1NC(/C=C/C2=CC=C(C3=CC=CC(C(F)(F)F)=C3)C=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 411.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhang H, Yu P, Lin H, Jin Z, Zhao S, Zhang Y, Xu Q, Jin H, Liu Z, Yang W, Zhang L. The Discovery of Novel ACA Derivatives as Specific TRPM2 Inhibitors that Reduce Ischemic Injury Both In Vitro and In Vivo. J Med Chem. 2021 Apr 8;64(7):3976-3996. doi: 10.1021/acs.jmedchem.0c02129. Epub 2021 Mar 30. PMID: 33784097.