WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555984

CAS#: 756487-18-0

Description: TKN87180 is a Hydrolyzable linker for making ADC conjugate. TKN87180 was first reported in Bioorganic & Medicinal Chemistry Letters (2004), 14(16), 4323-4327. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page:

Chemical Structure

CAS# 756487-18-0

Theoretical Analysis

MedKoo Cat#: 555984
Name: TKN87180
CAS#: 756487-18-0
Chemical Formula: C37H49N5O8
Exact Mass: 691.3581
Molecular Weight: 691.826
Elemental Analysis: C, 64.24; H, 7.14; N, 10.12; O, 18.50

Price and Availability

Size Price Availability Quantity
100.0mg USD 1150.0 2 Weeks
200.0mg USD 1650.0 2 Weeks
500.0mg USD 2650.0 2 Weeks
1.0g USD 3650.0 2 Weeks
2.0g USD 5850.0 2 Weeks
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Synonym: TKN87180; TKN-87180; TKN 87180;

IUPAC/Chemical Name: tert-butyl ((S)-5-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-phenylpropanamido)-6-((4-(hydroxymethyl)phenyl)amino)-6-oxohexyl)carbamate


InChi Code: InChI=1S/C37H49N5O8/c1-37(2,3)50-36(49)38-22-10-9-14-29(34(47)39-28-18-16-27(25-43)17-19-28)41-35(48)30(24-26-12-6-4-7-13-26)40-31(44)15-8-5-11-23-42-32(45)20-21-33(42)46/h4,6-7,12-13,16-21,29-30,43H,5,8-11,14-15,22-25H2,1-3H3,(H,38,49)(H,39,47)(H,40,44)(H,41,48)/t29-,30-/m0/s1


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 691.826 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Walker MA, King HD, Dalterio RA, Trail P, Firestone R, Dubowchik GM. Monoclonal antibody mediated intracellular targeting of tallysomycin S(10b). Bioorg Med Chem Lett. 2004 Aug 16;14(16):4323-7. doi: 10.1016/j.bmcl.2004.05.089. PMID: 15261295.


100.0mg / USD 1150.0