WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 200790
CAS#: 22560-50-5 (sodium )
Description: Clodronate sodium, also called clodronate disodium, is the disodium salt of a nitrogen-free bisphosphonate analog of naturally occurring pyrophosphate. Clodronate binds to calcium and inhibits osteoclastic bone resorption and hydroxyapatite crystal formation and dissolution, resulting in a reduction of bone turnover. This agent may control malignancy-associated hypercalcemia, inhibit osteolytic bone metastasis and decrease pain.
MedKoo Cat#: 200790
Name: Clodronate sodium
CAS#: 22560-50-5 (sodium )
Chemical Formula: CH2Cl2Na2O6P2
Molecular Weight: 288.86
Elemental Analysis: C, 4.16; H, 0.70; Cl, 24.55; Na, 15.92; O, 33.23; P, 21.45
Related CAS #: 22560-50-5 (sodium ) 10596-23-3 (free acid)
Synonym: Clodronate sodium; clodronic acid disodium salt; disodium dichloromethylene diphosphonate; Dichloromethylenediphosphonic acid disodium salt. Foreign brand names: Bonefos; Clasteon; Difosfonal; Loron; Mebonat; Ossiten. Code name: CL2MDP; DMDP.
IUPAC/Chemical Name: sodium (dichloromethylene)bis(hydrogenphosphonate)
InChi Key: ZEKKCKJNBVLJIO-UHFFFAOYSA-L
InChi Code: InChI=1S/CH4Cl2O6P2.2Na/c2-1(3,8-10(4)5)9-11(6)7;;/h10-11H,(H,4,5)(H,6,7);;/q;2*+1/p-2
SMILES Code: ClC(OP([O-])=O)(OP([O-])=O)Cl.[Na+].[Na+]
Appearance: white solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in water
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 288.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Muratore M, Quarta E, Grimaldi A, Calcagnile F, Quarta L. Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates. Drug Des Devel Ther. 2011;5:445-54. doi: 10.2147/DDDT.S12139. Epub 2011 Oct 19. Review. PubMed PMID: 22087064; PubMed Central PMCID: PMC3210073.
2: CrÃ©pin S, Laroche ML, Sarry B, Merle L. Osteonecrosis of the jaw induced by clodronate, an alkylbiphosphonate: case report and literature review. Eur J Clin Pharmacol. 2010 Jun;66(6):547-54. doi: 10.1007/s00228-010-0822-5. Epub 2010 May 1. Review. PubMed PMID: 20437036.
3: Machado M, Cruz LS, Tannus G, Fonseca M. Efficacy of clodronate, pamidronate, and zoledronate in reducing morbidity and mortality in cancer patients with bone metastasis: a meta-analysis of randomized clinical trials. Clin Ther. 2009 May;31(5):962-79. doi: 10.1016/j.clinthera.2009.05.009. Review. PubMed PMID: 19539097.
4: Volpi R, Rossi F, Trisi P, Testori T, Berardi D, Perfetti G. Pharmacologic modulation of clodronate in local therapy of periodontal and implant inflammation. Int J Immunopathol Pharmacol. 2007 Jan-Mar;20(1 Suppl 1):69-74. Review. PubMed PMID: 17897505.
5: Gulley J, Dahut WL. Clodronate in the prevention and treatment of skeletal metastasis. Expert Rev Anticancer Ther. 2005 Apr;5(2):221-30. Review. PubMed PMID: 15877520.
6: Dando TM, Wiseman LR. Clodronate : a review of its use in the prevention of bone metastases and the management of skeletal complications associated with bone metastases in patients with breast cancer. Drugs Aging. 2004;21(14):949-62. Review. PubMed PMID: 15554753.
7: van Rooijen N, van Kesteren-Hendrikx E. Clodronate liposomes: perspectives in research and therapeutics. J Liposome Res. 2002 Feb-May;12(1-2):81-94. Review. PubMed PMID: 12604042.
8: Ghinoi V, Brandi ML. Clodronate: mechanisms of action on bone remodelling and clinical use in osteometabolic disorders. Expert Opin Pharmacother. 2002 Nov;3(11):1643-56. Review. PubMed PMID: 12437497.
22560-50-5 (clodronate disodium)
10596-23-3 (clodronic acid)
Clodronic acid (INN) or clodronate disodium (USAN) is a bisphosphonate. It is used in experimental medicine to selectively deplete for macrophages. It is also approved for human use in Canada, the United Kingdom and Italy, where it is marketed as Bonefos, Loron and Clodron and prescribed as a bone resorption inhibitor and antihypercalcemic agent. (source: http://en.wikipedia.org/wiki/Clodronic_acid).