NV-5138
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MedKoo CAT#: 555979

CAS#: 2095886-80-7

Description: NV-5138[2] is an orally and centrally active small-molecule drug for the treatment of major depressive disorder (MDD). It directly and selectively activates the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway by binding to and modulating sestrin2, a leucine amino acid sensor and upstream regulatory pathway. The mTORC1 pathway is the same signaling pathway that the NMDA receptor antagonist ketamine activates in the medial prefrontal cortex (mPFC) to mediate its rapid-acting antidepressant effects. A single oral dose of NV-5138 has been found to increase mTORC1 signaling and produce synaptogenesis in the mPFC and to induce rapid antidepressant effects in multiple animal models of depression.


Chemical Structure

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NV-5138
CAS# 2095886-80-7

Theoretical Analysis

MedKoo Cat#: 555979
Name: NV-5138
CAS#: 2095886-80-7
Chemical Formula: C7H13F2NO2
Exact Mass: 181.0914
Molecular Weight: 181.1828
Elemental Analysis: C, 46.40; H, 7.23; F, 20.97; N, 7.73; O, 17.66

Price and Availability

Size Price Availability Quantity
100.0mg USD 1950.0 2 Weeks
200.0mg USD 2950.0 2 Weeks
500.0mg USD 3650.0 2 Weeks
1.0g USD 4650.0 2 Weeks
2.0g USD 7950.0 2 Weeks
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Synonym: NV-5138; NV 5138; NV5138;

IUPAC/Chemical Name: Pentanoic acid, 2-amino-5,5-difluoro-4,4-dimethyl-, (2S)-

InChi Key: HRFIMCJTDKEPPV-BYPYZUCNSA-N

InChi Code: InChI=1S/C7H13F2NO2/c1-7(2,6(8)9)3-4(10)5(11)12/h4,6H,3,10H2,1-2H3,(H,11,12)/t4-/m0/s1

SMILES Code: O=C(O)[C@@H](N)CC(C)(C)C(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 181.1828 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hasegawa Y, Zhu X, Kamiya A. NV-5138 as a fast-acting antidepressant via direct activation of mTORC1 signaling. J Clin Invest. 2019 May 20;129(6):2207-2209. doi: 10.1172/JCI129702. PMID: 31107245; PMCID: PMC6546442.

2: Kato T, Pothula S, Liu RJ, Duman CH, Terwilliger R, Vlasuk GP, Saiah E, Hahm S, Duman RS. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554. doi: 10.1172/JCI126859. PMID: 30990795; PMCID: PMC6546461.

3: Sengupta S, Giaime E, Narayan S, Hahm S, Howell J, O'Neill D, Vlasuk GP, Saiah E. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9(1):4107. doi: 10.1038/s41598-019-40693-5. PMID: 30858438; PMCID: PMC6412019.

NV-5138

100.0mg / USD 1950.0