Imiloxan hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576630

CAS#: 86710-23-8

Description: Imiloxan hydrochloride is an α2 adrenergic receptor antagonist potentially for the treatment of major depressive disorder.

Chemical Structure

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Imiloxan hydrochloride
CAS# 86710-23-8
Instruction

Theoretical Analysis

MedKoo Cat#: 576630
Name: Imiloxan hydrochloride
CAS#: 86710-23-8
Chemical Formula: C14H17ClN2O2
Exact Mass: 280.10
Molecular Weight: 280.750
Elemental Analysis: C, 59.89; H, 6.10; Cl, 12.63; N, 9.98; O, 11.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Imiloxan hydrochloride; Imiloxan HCl; RS-21361; RS 21361; RS21361

IUPAC/Chemical Name: (+-)-2-(1,4-Benzodioxan-2-ylmethyl)-1-ethylimidazole monohydrochloride

InChi Key: ANDJPJNFVJXEKX-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H16N2O2.ClH/c1-2-16-8-7-15-14(16)9-11-10-17-12-5-3-4-6-13(12)18-11;/h3-8,11H,2,9-10H2,1H3;1H

SMILES Code: Cl.CCn1ccnc1CC2COc3ccccc3O2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 280.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fitch WL, Chen Y, Liu L, Paehler A, Young M. Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan. Drug Metab Lett. 2010 Apr;4(2):77-87. PubMed PMID: 20446913.

2: Takano Y, Takano M, Yaksh TL. The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord. Eur J Pharmacol. 1992 Sep 4;219(3):465-8. PubMed PMID: 1358645.

3: Rush WR, Hall DJ, Graham DJ, Selby IA. The metabolism of imiloxan hydrochloride in healthy male volunteers. Xenobiotica. 1992 Feb;22(2):237-46. PubMed PMID: 1352928.

4: Michel AD, Loury DN, Whiting RL. Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Br J Pharmacol. 1990 Mar;99(3):560-4. PubMed PMID: 1970500; PubMed Central PMCID: PMC1917331.