WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464564
CAS#: unknown
Description: PTK-SMA1 is a unique promoter of SMN2 exon 7 splicing, acting by directly stimulating splicing of exon 7.
MedKoo Cat#: 464564
Name: PTK-SMA1
CAS#: unknown
Chemical Formula: C33H37N3O8
Exact Mass: 603.2581
Molecular Weight: 603.672
Elemental Analysis: C, 65.66; H, 6.18; N, 6.96; O, 21.20
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Synonym: PTK-SMA1; PTK SMA1; PTKSMA1;
IUPAC/Chemical Name: 3-((6aS,10S,10aS,11aR)-8-acetyl-10-(dimethylamino)-4,6,6a,9-tetrahydroxy-5,7-dioxo-5,6a,7,10,10a,11,11a,12-octahydrotetracen-1-yl)-N-(2-(dimethylamino)ethyl)benzamide
InChi Key: XMPRUTMMSAMKDI-ZFMGIHGMSA-N
InChi Code: InChI=1S/C33H37N3O8/c1-16(37)24-29(40)27(36(4)5)22-15-19-14-21-20(17-7-6-8-18(13-17)32(43)34-11-12-35(2)3)9-10-23(38)26(21)28(39)25(19)31(42)33(22,44)30(24)41/h6-10,13,19,22,27,38,40,42,44H,11-12,14-15H2,1-5H3,(H,34,43)/t19-,22-,27-,33+/m0/s1
SMILES Code: O=C(NCCN(C)C)C1=CC=CC(C2=CC=C(O)C3=C2C[C@]4([H])C(C3=O)=C(O)[C@@](C(C(C(C)=O)=C(O)[C@H]5N(C)C)=O)(O)[C@@]5([H])C4)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 603.672 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Hastings ML, Berniac J, Liu YH, Abato P, Jodelka FM, Barthel L, Kumar S, Dudley C, Nelson M, Larson K, Edmonds J, Bowser T, Draper M, Higgins P, Krainer AR. Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy. Sci Transl Med. 2009 Nov 4;1(5):5ra12. doi: 10.1126/scitranslmed.3000208. PMID: 20161659; PMCID: PMC2818805.
