Icotidine hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 576542

CAS#: 71351-65-0

Description: Icotidine hydrochloride is an antagonist of histamine at both H1 and H2 receptors.


Chemical Structure

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Icotidine hydrochloride
CAS# 71351-65-0

Theoretical Analysis

MedKoo Cat#: 576542
Name: Icotidine hydrochloride
CAS#: 71351-65-0
Chemical Formula: C21H28Cl3N5O2
Exact Mass: 487.13
Molecular Weight: 488.840
Elemental Analysis: C, 51.60; H, 5.77; Cl, 21.76; N, 14.33; O, 6.55

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Icotidine hydrochloride; Icotidine HCl; SKF 93319; SKF93319; SKF-93319

IUPAC/Chemical Name: 4(1H)-Pyrimidinone, 2-((4-(3-methoxy-2-pyridinyl)butyl)amino)-5-((6-methyl-3-pyridinyl)methyl)-, trihydrochloride

InChi Key: NFXGPXPZKQLGKZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H25N5O2.3ClH/c1-15-8-9-16(13-24-15)12-17-14-25-21(26-20(17)27)23-10-4-3-6-18-19(28-2)7-5-11-22-18;;;/h5,7-9,11,13-14H,3-4,6,10,12H2,1-2H3,(H2,23,25,26,27);3*1H

SMILES Code: Cl.Cl.Cl.COc1cccnc1CCCCNC2=NC=C(Cc3ccc(C)nc3)C(=O)N2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 488.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Ganellin CR, Blakemore RC, Brown TH, Cooper DG, Durant GJ, Harvey CA, Ife RJ, Owen DA, Parsons ME, Rasmussen AC, et al. Icotidine, an antagonist of histamine at both H1 and H2 receptors. N Engl Reg Allergy Proc. 1986 Mar-Apr;7(2):126-33. doi: 10.2500/108854186779047762. PMID: 2886901.

2. Abacioglu N, Bediz A, Cakici I, Tunçtan B, Kanzik I. Antinociceptive effects of H1- and H2-antihistaminics in mice. Gen Pharmacol. 1993 Sep;24(5):1173-6. doi: 10.1016/0306-3623(93)90365-5. PMID: 7903650.