Atglistatin
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MedKoo CAT#: 510273

CAS#: 1469924-27-3

Description: Atglistatin is a potent and selective adipose triglyceride lipase (ATGL) inhibitor. ATGL is rate limiting in the mobilization of fatty acids from cellular triglyceride stores. This central role in lipolysis marks ATGL as an interesting pharmacological target as deregulated fatty acid metabolism is closely linked to dyslipidemic and metabolic disorders. Atglistatin is selective for ATGL and reduces fatty acid mobilization in vitro and in vivo.


Chemical Structure

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Atglistatin
CAS# 1469924-27-3

Theoretical Analysis

MedKoo Cat#: 510273
Name: Atglistatin
CAS#: 1469924-27-3
Chemical Formula: C17H21N3O
Exact Mass: 283.16846
Molecular Weight: 283.37
Elemental Analysis: C, 72.06; H, 7.47; N, 14.83; O, 5.65

Size Price Shipping out time Quantity
10mg USD 150 Same Day
25mg USD 250 Same Day
50mg USD 450 Same Day
100mg USD 850 Same Day
200mg USD 1150 Same Day
Inquire bulk and customized quantity

Pricing updated 2021-02-28. Prices are subject to change without notice.

Atglistatin, purity > 98%, is in stock. The same day shipping out after order is received.

Synonym: Atglistatin

IUPAC/Chemical Name: 3-(4'-(dimethylamino)-[1,1'-biphenyl]-3-yl)-1,1-dimethylurea

InChi Key: AWOPBSAJHCUSAS-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)

SMILES Code: CN(C1=CC=C(C=C1)C2=CC(NC(N(C)C)=O)=CC=C2)C

Appearance:
white to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 283.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: MacPherson RE, Dragos SM, Ramos S, Sutton C, Frendo-Cumbo S, Castellani L, Watt MJ, Perry CG, Mutch DM, Wright DC. Reduced ATGL-mediated lipolysis attenuates β-adrenergic-induced AMPK signaling, but not the induction of PKA-targeted genes, in adipocytes and adipose tissue. Am J Physiol Cell Physiol. 2016 Aug 1;311(2):C269-76. doi: 10.1152/ajpcell.00126.2016. Epub 2016 Jun 29. PubMed PMID: 27357546.

2: Tuohetahuntila M, Molenaar MR, Spee B, Brouwers JF, Houweling M, Vaandrager AB, Helms JB. ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells. J Lipid Res. 2016 Jul;57(7):1162-74. doi: 10.1194/jlr.M066415. Epub 2016 May 14. PubMed PMID: 27179362; PubMed Central PMCID: PMC4918846.

3: Roy PP, D'Souza K, Cuperlovic-Culf M, Kienesberger PC, Touaibia M. New Atglistatin closely related analogues: Synthesis and structure-activity relationship towards adipose triglyceride lipase inhibition. Eur J Med Chem. 2016 Aug 8;118:290-8. doi: 10.1016/j.ejmech.2016.04.021. Epub 2016 Apr 10. PubMed PMID: 27155760.

4: Lee SJ, Duncan DS, Echevarria FD, McLaughlin WM, Hatcher JB, Sappington RM. Pressure-Induced Alterations in PEDF and PEDF-R Expression: Implications for Neuroprotective Signaling in Glaucoma. J Clin Exp Ophthalmol. 2015 Oct;6(5). pii: 491. Epub 2015 Oct 27. PubMed PMID: 26807306; PubMed Central PMCID: PMC4721587.

5: Iglesias J, Lamontagne J, Erb H, Gezzar S, Zhao S, Joly E, Truong VL, Skorey K, Crane S, Madiraju SR, Prentki M. Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors. J Lipid Res. 2016 Jan;57(1):131-41. doi: 10.1194/jlr.D058438. Epub 2015 Sep 30. PubMed PMID: 26423520; PubMed Central PMCID: PMC4689331.

6: Kobayashi H, Nishimura H, Matsumoto K, Yoshida M. Identification of the determinants of 2-deoxyglucose sensitivity in cancer cells by shRNA library screening. Biochem Biophys Res Commun. 2015 Nov 6;467(1):121-7. doi: 10.1016/j.bbrc.2015.09.106. Epub 2015 Sep 25. PubMed PMID: 26403972.

7: Zagani R, El-Assaad W, Gamache I, Teodoro JG. Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells. Oncotarget. 2015 Sep 29;6(29):28282-95. doi: 10.18632/oncotarget.5061. PubMed PMID: 26318046; PubMed Central PMCID: PMC4695060.

8: Zhang H, Sun T, Jiang X, Yu H, Wang M, Wei T, Cui H, Zhuang W, Liu Z, Zhang Z, Dong H. PEDF and PEDF-derived peptide 44mer stimulate cardiac triglyceride degradation via ATGL. J Transl Med. 2015 Feb 21;13:68. doi: 10.1186/s12967-015-0432-1. PubMed PMID: 25890298; PubMed Central PMCID: PMC4344780.

9: Cerk IK, Salzburger B, Boeszoermenyi A, Heier C, Pillip C, Romauch M, Schweiger M, Cornaciu I, Lass A, Zimmermann R, Zechner R, Oberer M. A peptide derived from G0/G1 switch gene 2 acts as noncompetitive inhibitor of adipose triglyceride lipase. J Biol Chem. 2014 Nov 21;289(47):32559-70. doi: 10.1074/jbc.M114.602599. Epub 2014 Sep 25. PubMed PMID: 25258314; PubMed Central PMCID: PMC4239610.

10: Mayer N, Schweiger M, Romauch M, Grabner GF, Eichmann TO, Fuchs E, Ivkovic J, Heier C, Mrak I, Lass A, Höfler G, Fledelius C, Zechner R, Zimmermann R, Breinbauer R. Development of small-molecule inhibitors targeting adipose triglyceride lipase. Nat Chem Biol. 2013 Dec;9(12):785-7. doi: 10.1038/nchembio.1359. Epub 2013 Oct 6. PubMed PMID: 24096302; PubMed Central PMCID: PMC3829776.



Additional Information

 License information:
This product is produced and sold under the license of University of Graz / Graz University of Technology.