WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 464539
CAS#: unknown
Description: Pyridinone-14 is a novel highly potent agonist of the apelin receptor (APJ; cAMP EC50: human 0.023nM; rat 0.024nM; dog 0.030nM; monkey 0.080nM).
MedKoo Cat#: 464539
Name: Pyridinone-14
CAS#: unknown
Chemical Formula: C24H23ClN4O6
Exact Mass: 498.1306
Molecular Weight: 498.92
Elemental Analysis: C, 57.78; H, 4.65; Cl, 7.11; N, 11.23; O, 19.24
This product is not in stock, which may be available by custom synthesis.
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Synonym: Pyridinone-14; Pyridinone 14;
IUPAC/Chemical Name: 3-(5-((5-chloropyridin-2-yl)methyl)-1,3,4-oxadiazol-2-yl)-5-(2,6-dimethoxyphenyl)-6-(ethoxymethyl)-4-hydroxypyridin-2(1H)-one
InChi Key: AGZKELPIAJYRDT-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H23ClN4O6/c1-4-34-12-15-19(20-16(32-2)6-5-7-17(20)33-3)22(30)21(23(31)27-15)24-29-28-18(35-24)10-14-9-8-13(25)11-26-14/h5-9,11H,4,10,12H2,1-3H3,(H2,27,30,31)
SMILES Code: O=C1C(C2=NN=C(CC3=NC=C(Cl)C=C3)O2)=C(O)C(C4=C(OC)C=CC=C4OC)=C(COCC)N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 498.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Johnson JA, Kim SH, Jiang J, Phillips M, Schumacher WA, Bostwick JS, Gargalovic PS, Onorato JM, Luk CE, Generaux C, He Y, Chen XQ, Xu C, Galella MA, Wang T, Gordon DA, Wexler RR, Finlay HJ. Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate. J Med Chem. 2021 Mar 25;64(6):3086-3099. doi: 10.1021/acs.jmedchem.0c01878. Epub 2021 Mar 9. PMID: 33689340.
