EN4 MYC inhibitor
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MedKoo CAT#: 408138

CAS#: 1197824-15-9

Description: EN4 is a functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. EN4 functionally and covalently targets an intrinsically disordered region in MYC. EN4 directly targets MYC in cells and reduces MYC and MAX thermal stability. EN4 inhibits MYC activity, downregulates MYC targets, and impairs tumorigenesis. MYC is a major oncogenic transcriptional driver of most human cancers that has remained intractable to direct targeting because much of MYC is intrinsically disordered.


Chemical Structure

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EN4 MYC inhibitor
CAS# 1197824-15-9

Theoretical Analysis

MedKoo Cat#: 408138
Name: EN4 MYC inhibitor
CAS#: 1197824-15-9
Chemical Formula: C25H24N2O4
Exact Mass: 416.1736
Molecular Weight: 416.477
Elemental Analysis: C, 72.10; H, 5.81; N, 6.73; O, 15.37

Price and Availability

Size Price Availability Quantity
25.0mg USD 250.0 2 Weeks
50.0mg USD 450.0 2 Weeks
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 2250.0 2 Weeks
1.0g USD 3250.0 2 Weeks
2.0g USD 5650.0 2 Weeks
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Synonym: EN4 MYC inhibitor; EN4; EN-4; EN 4.

IUPAC/Chemical Name: 4-(acrylamidomethyl)-N-(2-(4-ethoxyphenoxy)phenyl)benzamide

InChi Key: DKOWGKKELPCHEG-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H24N2O4/c1-3-24(28)26-17-18-9-11-19(12-10-18)25(29)27-22-7-5-6-8-23(22)31-21-15-13-20(14-16-21)30-4-2/h3,5-16H,1,4,17H2,2H3,(H,26,28)(H,27,29)

SMILES Code: CCOC(C=C1)=CC=C1OC2=C(NC(C3=CC=C(CNC(C=C)=O)C=C3)=O)C=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 416.477 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Boike L, Cioffi AG, Majewski FC, Co J, Henning NJ, Jones MD, Liu G, McKenna JM, Tallarico JA, Schirle M, Nomura DK. Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17. doi: 10.1016/j.chembiol.2020.09.001. Epub 2020 Sep 22. PMID: 32966806; PMCID: PMC7854864.