2-hATQ
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464493

CAS#: 605-32-3

Description: 2-Hydroxyanthraquinone is an anthraquinone that has been found in Spermacoce latifolia and has antibacterial and estrogenic activities. It is active against B. subtilis and B. cereus (MICs = 1.9 and 62.5 µg/ml, respectively). 2-Hydroxyanthraquinone (19 µM) induces estrogen receptor α (ERα) activation in a yeast two-hybrid assay.


Chemical Structure

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2-hATQ
CAS# 605-32-3

Theoretical Analysis

MedKoo Cat#: 464493
Name: 2-hATQ
CAS#: 605-32-3
Chemical Formula: C14H8O3
Exact Mass: 224.0473
Molecular Weight: 224.215
Elemental Analysis: C, 75.00; H, 3.60; O, 21.41

Price and Availability

Size Price Availability Quantity
5.0g USD 210.0 2 Weeks
10.0g USD 350.0 2 Weeks
25.0g USD 560.0 2 Weeks
50.0g USD 840.0 2 Weeks
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Synonym: 2-hATQ; 2 hATQ; 2-Hydroxyanthraquinone; 2 Hydroxyanthraquinone; 2-hydroxy-9,10-Anthraquinone; β-Hydroxyanthraquinone; β Hydroxyanthraquinone; NSC 2595; NSC2595; NSC-2595;

IUPAC/Chemical Name: 2-hydroxyanthracene-9,10-dione

InChi Key: GCDBEYOJCZLKMC-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H8O3/c15-8-5-6-11-12(7-8)14(17)10-4-2-1-3-9(10)13(11)16/h1-7,15H

SMILES Code: O=C1C2=C(C=CC=C2)C(C3=CC(O)=CC=C13)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMF 5.0 22.3
DMSO 30.0 133.8

Preparing Stock Solutions

The following data is based on the product molecular weight 224.215 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Butterworth BE, Mathre OB, Ballinger KE, Adalsteinsson O. Contamination is a frequent confounding factor in toxicology studies with anthraquinone and related compounds. Int J Toxicol. 2004;23(5):335-44. doi: 10.1080/10915810490517072. PMID: 15513832.

2: Mallakin A, McConkey BJ, Miao G, McKibben B, Snieckus V, Dixon DG, Greenberg BM. Impacts of structural photomodification on the toxicity of environmental contaminants: anthracene photooxidation products. Ecotoxicol Environ Saf. 1999 Jun;43(2):204-12. doi: 10.1006/eesa.1999.1764. PMID: 10375423.

3: Ramamoorthy S, Mudgal G, Rajesh D, Nawaz Khan F, Vijayakumar V, Rajasekaran C. Characterisation of novel pH indicator of natural dye Oldenlandia umbellata L. Nat Prod Res. 2009;23(13):1210-7. doi: 10.1080/14786410802696635. PMID: 19731140.

4: Shi Y, Wang CH, Gong XG. Apoptosis-inducing effects of two anthraquinones from Hedyotis diffusa WILLD. Biol Pharm Bull. 2008 Jun;31(6):1075-8. doi: 10.1248/bpb.31.1075. PMID: 18520033.

5: Tikkanen L, Matsushima T, Natori S. Mutagenicity of anthraquinones in the Salmonella preincubation test. Mutat Res. 1983 Mar;116(3-4):297-304. doi: 10.1016/0165-1218(83)90067-8. PMID: 6339896.

6: Hilgert I, Cudlín J, Steinerová N, Vanĕk Z. Antitumour and immunosuppressive activity of hydroxyanthraquinones and their glucosides. Folia Biol (Praha). 1977;23(2):99-109. PMID: 863051.

2-hATQ

100.0mg / Not available