WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 464491

CAS#: 3106-85-2

Description: α-NAAG is a peptide neurotransmitter that is widely expressed throughout mammalian central and peripheral nervous systems. Following synaptic release, α-NAAG activates postsynaptic metabotropic glutamate receptor 3 (mGluR3) to inhibit cAMP production in neurons and astrocytes, as well as acts on presynaptic mGluR3 to inhibit the release of amine neurotransmitters, including GABA and glutamate. Increasing α-NAAG levels via NAAG peptidase inhibition reduces trauma-induced excitotoxic cell death in a mouse model of traumatic brain injury, as well as reduces hyperalgesia in various rodent pain models and schizophrenia-like stereotypic behaviors induced by phencyclidine in rats. Tumor levels of α-NAAG are positively correlated with tumor grade in patients with gliomas and meningiomas.

Chemical Structure

CAS# 3106-85-2

Theoretical Analysis

MedKoo Cat#: 464491
Name: NAAG
CAS#: 3106-85-2
Chemical Formula: C11H16N2O8
Exact Mass: 304.0907
Molecular Weight: 304.255
Elemental Analysis: C, 43.42; H, 5.30; N, 9.21; O, 42.07

Price and Availability

Size Price Availability Quantity
10.0mg USD 230.0 2 Weeks
50.0mg USD 430.0 2 Weeks
100.0mg USD 700.0 2 Weeks
250.0mg USD 1200.0 2 Weeks
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Synonym: NAAG; α-NAAG; α NAAG; N-Acetylaspartylglutamic Acid; N Acetylaspartylglutamic Acid; α-Spaglumic Acid; α Spaglumic Acid;

IUPAC/Chemical Name: acetyl-L-aspartyl-L-glutamic acid


InChi Code: InChI=1S/C11H16N2O8/c1-5(14)12-7(4-9(17)18)10(19)13-6(11(20)21)2-3-8(15)16/h6-7H,2-4H2,1H3,(H,12,14)(H,13,19)(H,15,16)(H,17,18)(H,20,21)/t6-,7-/m0/s1

SMILES Code: OC(CC[C@H](NC([C@H](CC(O)=O)NC(C)=O)=O)C(O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMF 20.0 65.7
DMSO 20.0 65.7
Ethanol 20.0 65.7
PBS (pH 7.2) 10.0 32.9

Preparing Stock Solutions

The following data is based on the product molecular weight 304.255 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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12: Raider K, Ma D, Harris JL, Fuentes I, Rogers RS, Wheatley JL, Geiger PC, Yeh HW, Choi IY, Brooks WM, Stanford JA. A high fat diet alters metabolic and bioenergetic function in the brain: A magnetic resonance spectroscopy study. Neurochem Int. 2016 Jul;97:172-80. doi: 10.1016/j.neuint.2016.04.008. Epub 2016 Apr 26. PMID: 27125544; PMCID: PMC4900919.

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10.0mg / USD 230.0