BUN49048
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MedKoo CAT#: 555970

CAS#: 2095849-04-8

Description: BUN49048, also known as CSF1R-IN-1, is a CSF1R inhibitor with an with an IC50 of 0.5 nM. BUN49048 was first reported in Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160. This product has not formal name. For the convenience of scientific communication, we named it by combining its Inchi key (3 letters from the first letter of each section) with the last 5 digit of its CAS#) according to MedKoo Chemical Nomenclature (https://www.medkoo.com/page/naming).


Chemical Structure

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BUN49048
CAS# 2095849-04-8

Theoretical Analysis

MedKoo Cat#: 555970
Name: BUN49048
CAS#: 2095849-04-8
Chemical Formula: C25H20F3N5O2
Exact Mass: 479.1569
Molecular Weight: 479.4632
Elemental Analysis: C, 62.63; H, 4.20; F, 11.89; N, 14.61; O, 6.67

Price and Availability

Size Price Availability Quantity
100.0mg USD 950.0 2 Weeks
200.0mg USD 1450.0 2 Weeks
500.0mg USD 2850.0 2 Weeks
1.0g USD 3650.0 2 Weeks
2.0g USD 5850.0 2 Weeks
5.0g USD 8650.0 2 Weeks
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Synonym: CSF1R-IN-1; BUN49048; BUN-49048; BUN 49048;

IUPAC/Chemical Name: 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide

InChi Key: BMEXIUCHJUGPRB-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H20F3N5O2/c1-15-6-7-21(31-23(34)16-4-3-5-20(9-16)25(26,27)28)10-22(15)32-24(35)18-8-17(11-29-12-18)19-13-30-33(2)14-19/h3-14H,1-2H3,(H,31,34)(H,32,35)

SMILES Code: CC1=CC=C(NC(C2=CC=CC(C(F)(F)F)=C2)=O)C=C1NC(C3=CC(C4=CN(C)N=C4)=CN=C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 479.4632 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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[1]. Ramachandran SA, et al. Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors. Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160.

BUN49048

100.0mg / USD 950.0